卡托普利片生物等效性研究基本考虑

General consideration for the bioequivalence study of captopril tablets

卡托普利为血管紧张素转换化酶抑制药,其制剂临床上用于治疗高血压和心力衰竭。由于其化学结构的特殊性,在生物等效性研究的生物样品分析过程中,需要对样品处理方法、检测方法进行充分考察,所用方法不同,最终得出的检测结果也不尽相同。无论采用何种处理方法,都应对该方法进行科学全面的验证,以确保最终结果的可靠性。

Captopril is an angiotensin converting enzyme inhibitor,and its preparation is used to the treatment of hypertension and heart failure.Due to the particularity of its chemical structure,in the biological sample analysis process of bioequivalence research,it is necessary to fully investigate the sample processing method and detection method.The final results are different by different methods.No matter which treatment method is adopted,it should be verified scientifically and comprehensively to ensure the reliability of the final result.