组胺H3受体反向激动剂在神经系统疾病中应用的研究现状

Research status in the application of histamine H3 receptor inverse agonists in nervous system diseases

组胺H3受体不仅参与调节脑内组胺的合成、释放与代谢,还能调节其他多种神经递质的释放与代谢。近几十年来,在组胺H3受体拮抗剂的基础上,提出组胺H3受体反向激动剂的概念。目前,已发现的组胺H3受体反向激动剂涉及睡眠-觉醒障碍、认知障碍、抑郁、神经性疼痛等多种神经系统疾病。然而在众多的组胺H3受体反向激动剂相关文献中,组胺H3受体反向激动剂应用的研究进展的综述却较少见。本文通过调研国内和国外文献,重点阐述了组胺H3受体反向激动剂在神经系统疾病中的最新研究进展。

The histamine H3 receptor is not only involved in the regulation of the synthesis,release and metabolism of histamine in the brain,but also significantly regulates the release and metabolism of many neurotransmitters.In recent years,based on the studies connected with histamine H3 receptor antagonists,the concept of histamine H3 receptor inverse agonist has been proposed.Histamine H3 inverse agonists involve in sleep-wake disorders,cognition,depression and other nervous system diseases.However,among numorous literatures related to histamine H3 receptor inverse agonists,the summary of histamine H3 receptor inverse agonist applications is in scanty.This article focuses on the latest research progress in the histamine H3 receptor inverse agonists’application in nervous system diseases by investigating domestic and foreign literatures.