辅助性T细胞在骨关节炎发病机制中的作用

The role of helper T cell in the pathogenesis of osteoarthritis

目的总结辅助性T细胞(helper T cell,Th)在骨关节炎(osteoarthritis,OA)发病机制中的作用及与Th细胞相关的OA治疗研究进展。方法广泛查阅国内外相关文献,对Th细胞[Th1、Th2、Th9、Th17、Th22细胞以及滤泡性辅助T细胞(follicular helper T cell,Tfh)]及其细胞因子在OA发病机制中的作用、有关治疗研究进展进行总结。结果Th细胞在OA发病机制中起到重要作用。目前研究表明,Th1、Th9、Th17细胞在OA发病机制中的作用明显大于Th2、Th22、Tfh细胞,TNF-α、IL-17等细胞因子对关节软骨有明显破坏作用。结论Th细胞在OA发病机制中的作用仍处于探索阶段,调节Th细胞的细胞因子、细胞内外信号和细胞代谢是防治OA的潜在方法。

Objective To review and summarize the role of helper T cell(Th)in the pathogenesis of osteoarthritis(OA)and research progress of Th cell-related treatment for OA.Methods The domestic and foreign literature in recent years was reviewed.The role of Th cells[Th1,Th2,Th9,Th17,Th22,and follicular helper T cell(Tfh)]and related cytokines in the pathogenesis of OA and the latest research progress of treatment were summarized.Results Th cells play an important role in the pathogenesis of OA.Th1,Th9,and Th17 cells are more important than Th2,Th22,and Tfh cells in the pathogenesis of OA.Cytokines such as tumor necrosis factorαand interleukin 17 can cause damage to articular cartilage significantly.Conclusion At present,the role of Th cells in the pathogenesis of OA has been played in the spotlight.The specific mechanism has not been clear.Regulating the Th cell-associated cytokines,intracellular and extracellular signals,and cellular metabolism is a potential method for prevention and treatment of OA.