胃腺癌中Lgr5与Ki67的表达及临床意义

Expression and significance of marker Lgr5 and Ki67 in gastric adenocarcinoma

目的探讨Lgr5、Ki67蛋白在胃腺癌中的表达及临床意义。方法采用免疫组化MaxVision两步法检测胃腺癌及癌旁组织中Lgr5及Ki67的表达,分析它们与胃腺癌临床病理参数之间的关系及两者表达的相关性。结果与癌旁组织相比,Lgr5与Ki67蛋白在胃腺癌中表达均上调,阳性率分别为30.8%及33.3%,且两者表达均与脉管瘤栓、淋巴结转移及临床分期相关(P<0.05),Lgr5与Ki67在胃腺癌中的表达呈正相关(r=0.255,P<0.01)。结论 Lgr5、Ki67与胃腺癌的发生、发展密切相关,在胃腺癌演进过程中两者可能存在协同作用。

To explore the expression and clinical significance of Lgr5 and Ki67 in gastric adenocarcinoma. Methods The expressions of Lgr5 and Ki67 in gastric adenocarcinoma and corresponding adjacent tissues were detected by MaxVision immunohistochemical staining. The relationship between Lgr5 and Ki67 with every pathologic parameters of gastric adenocarcinoma,and the relevance of their expression,were analyzed statistically. Results Compared with paracancerous tissue,Lgr5 and Ki67 were over expressed in gastric adenocarinoma,and the positive rates of Lgr5 and Ki67 were 30.8% and 33.3%. The expression of Lgr5 and Ki67 were both associated with vascular tumor thrombus, lymph node metastasis and clinical stage in patients with gastric adenocarcinoma(P<0.05). There was a positive correlation between the expression of Lgr5 and Ki67 in gastric adenocarcinoma tissues(r=0.255,P<0.01). Conclusion The markers Lgr5 and Ki67 are closely related to the occurrence and development of gastric adenocarcinoma, which may play a synergistic role in the evolution of gastric adenocarcinoma.