群体感应在动态代谢调控中的研究进展

Research Progress on the Quorum Sensing in the Dynamic Metabolic Regulation

群体感应(quorum sensing,QS)是一种特殊的动态代谢调控机制,是细菌用于监控自身群体密度的环境信号感受系统。近年来,随着合成生物学的大力发展,基于稳定的菌群关系的人工合成菌群以及混菌共培养技术也取得了突破性的进展。群体感应系统因为可以实现细菌自主控制菌群关系的目的,而在菌群关系构建以及代谢工程中的研究和应用受到越来越多的关注。在对群体感应系统进行概述的基础上,对单菌基于群体感应的动态代谢调控进行了总结;同时也对群体感应的动态调控在革兰氏阴性菌和革兰氏阳性菌之间以及混菌共培养过程中的研究进展进行综述,以期能对群体感应系统的其他应用提供一些建议和帮助。

Quorum sensing is a special dynamic metabolic regulation mechanism.It is an environmental signal sensing system used by bacteria to monitor their own population densities.In recent years,with the vigorous development of synthetic biology,breakthroughs have also been made in the artificially synthesized flora and mixed bacteria co-culture technology based on stable flora relations.The quorum sensing system can achieve the purpose of autonomously controlling the relationship between bacteria and bacteria,and its research and application in metabolic engineering has received more and more attention.Based on the overview of quorum sensing,this paper summarizes the dynamic metabolic regulation of single bacteria based on quorum sensing;at the same time,research progress in the dynamic regulation of quorum sensing between Gram-negative and Gram-positive bacteria and co-cultivation is reviewed.In order to provide some suggestions and help for other quorum sensing applications.