积雪草总苷对隆乳术后包膜挛缩治疗作用的临床研究

Clinical study on the effect of Centella asiatica on capsular contracture after breast augmentation

目的探讨积雪草总苷治疗包膜挛缩(CC)的临床疗效。方法选取2017年1月至2019年3月于该院就诊的Baker分级Ⅳ级CC患者80例,分为对照组、低剂量组、中剂量组、高剂量组,每组20例。对照组给予安慰剂,低、中、高剂量组均给予积雪草总苷,分别每次12、16、24 mg,均为3次/天。持续治疗6个月后,计算治疗总有效率、疼痛缓解率、假体压缩率,记录不良反应发生情况。结果对照组、低剂量组、中剂量组及高剂量组的治疗总有效率分别为0、40.0%、85.0%、95.0%,疼痛缓解率分别为0、10.0%、45.0%、80.0%,假体压缩率分别为(55.75±1.16)%、(57.54±1.09)%、(65.08±0.79)%、(72.76±0.98)%,各组间比较,差异均有统计学意义(P<0.05);且高剂量组的总有效率、疼痛缓解率及假体压缩率均高于中、低剂量组。高、中、低剂量组的不良反应发生率比较,差异无统计学意义(P>0.05)。结论积雪草总苷能有效治疗CC,且具有一定的镇痛作用;在药物使用剂量的安全范围内,剂量越高治疗效果越好,但不良反应发生率有增高趋势。

Objective To investigate the clinical efficacy of Centella asiatica in the treatment of capsular contracture(CC).Methods A total of 80 cases of patients with Baker gradeⅣCC in the hospital from January 2017 to March 2019 were selected and divided into the control group,the low dose group,the middle dose group and the high dose group,20 cases in each group.The control group was treated with placebo,and the low,medium and high dose groups were treated with Centella asiatica at 12,16,and 24 mg each time,3 times each day.After 6 months of continuous treatment,the total effective rate,pain relief rate,prosthesis compression rate were calculated,and adverse reactions were measured.Results The total effective rates in the control group,the low-dose group,the middle-dose group and the high-dose group were 0,40.0%,85.0%and 95.0%,respectively;the pain relief rates were 0,10.0%,45.0%and 80.0%,respectively;the compression ratios were(55.75±1.16)%,(57.54±1.09)%,(65.08±0.79)%and(72.76±0.98)%,respectively;the differences among the groups were statistically significant(P<0.05).The total effective rate,pain relief rate and compression rate in the high-dose group were higher than those in the middle-dose group and the low-dose group.There was no statistically significant difference in the incidence of adverse reactions among the high,medium and low dose groups(P>0.05).Conclusion Centella asiatica can effectively treat CC,and has a certain analgesic effect.Within the safe range of drug dosage,the higher the dosage,the better the therapeutic effect,but with an increasing trend of the incidence of adverse reactions.