重唇石斛化学成分研究

Chemical constituents of Dendrobium hercoglossum

目的研究兰科石斛属植物重唇石斛Dendrobium hercoglossum的化学成分。方法采用各种柱色谱及制备液相色谱分离纯化,经波谱数据鉴定化合物结构。结果从重唇石斛全草的醋酸乙酯提取物中分离得到10个化合物,其结构分别鉴定为3,4,α-三羟基-5,3′-二甲氧基联苄(1)、4,α-二羟基-3,5,3′-三甲氧基联苄(2)、4,5-二羟基-3,3′,α-三甲氧基联苄(3)、4,3′-二羟基-3,5-二甲氧基联苄(4)、4,4′-二羟基-3,5,3′-三甲氧基联苄(5)、N-反式桂皮酸酰对羟基苯乙胺(6)、原儿茶酸(7)、香草醇(8)、1-正十六烷酸甘油酯(9)、丁香脂素(10)。结论化合物1为新化合物,命名为重唇石斛素A,其余化合物均为首次从该植物中分离得到。

Objective To study the chemical constituents of Dendrobium hercoglossum.Methods The compounds were isolated and purified by column chromatography and preparative HPLC,and their chemical structures were identified on the basis of spectral analysis.Results Ten compounds were isolated and identified as 3,4,α-trihydroxy-5,3′-dimethoxybibenzyl(1),4,α-dihydroxy-3,5,3′-trimethoxybibenzyl(2),4,5-dihydroxy-3,3′,α-trimethoxybibenzyl(3),4,3′-dihydroxy-3,5-dimethoxybibenzyl(4),4,4′-dihydroxy-3,5,3′-trimethoxybibenzyl(5),N-trans-cinnamoyltyramine(6),protocatechuic acid(7),vanillyl alcohol(8),hexadecanoic acid 2,3-dihydroxypropyl ester(9)and syringaresinol(10).Conclusion Compound 1 is a new compound,named dendhercoine A,compounds 2—10 are isolated from this plant for the first time.