摘要
棕色脂肪组织(BAT)是由棕色脂肪细胞和血管基质成分(SVF)组成,其中SVF中包括内皮细胞、淋巴细胞、成纤维细胞以及具有多种分化功能的干细胞,在调节心血管健康与疾病上扮演着重要角色,参与心血管疾病的发生与发展。一方面,BAT通过能量代谢以及自分泌或旁分泌方式分泌的细胞因子对机体产生重要影响。BAT可以作用于心血管系统,发挥抗炎、抗心室重构等作用,从而对心血管起到保护作用。另一方面,脂肪组织来源干细胞的发现与应用,也为心血管疾病的治疗提供了有效途径。本文回顾了BAT自发现以来在人体及动物模型上的相关研究进展,论述了其与心血管损伤的相关性。
Brown adipose tissue(BAT)is composed of brown adipocytes and vascular matrix components(SVF),including endothelial cells,lymphocytes,fibroblasts and stem cells with multiple differentiation functions,which is of great significance to cardiovascular health and the occurrence and development of cardiovascular diseases.At the same time,BAT exerts an important influence on the body through the way of energy metabolism and cytokines secreted in an autocrine or paracrine.BAT has a positive effect on the cardiovascular system,and has anti-inflammatory as well as anti-ventricular remodeling effects,thus protecting cardiovascular system.The discovery and application of adipose-derived stem cells cells also provide an effective way for the treatment of cardiovascular diseases.This article reviews the related BAT researches in human and animal models since its discovery,and discusses its relationship with cardiovascular injury.
作者
陈宏锦
潘晓茜
高平进
阮承超
Chen Hongjin;Pan Xiaoxi;Gao Pingjin;Ruan Chengchao(State Key Laboratory of Medical Genomics,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China;Shanghai Key Laboratory of Hypertension,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China)
出处
《中华细胞与干细胞杂志（电子版）》
2020年第3期182-186,共5页
Chinese Journal of Cell and Stem Cell（Electronic Edition）
基金
国家自然科学基金(81922004)。
