艾司西酞普兰与舍曲林治疗门诊抑郁症的对照研究

A comparative study of escitalopram and sertraline in the treatment of outpatients with depression

目的对比门诊抑郁症患者的治疗中应用艾司西酞普兰与舍曲林的不同效果。方法回顾性分析2016年1月~2017年4月某院门诊收治的抑郁症患者84例,将其中接受艾司西酞普兰治疗的42例患者作为观察组,另外42例患者接受舍曲林治疗作为对照组,对比两组临床效果。结果观察组治疗后总有效率为83.33%,对照组治疗后总有效率54.76%,差异有统计学意义(P<0.05);观察组治疗8周后HAMD评分为(13.26±2.15)分,对照组治疗8周后HAMD评分为(20.59±2.64)分,差异有统计学意义(P<0.05);观察组不良反应发生率为7.14%,对照组不良反应发生率为26.19%,差异有统计学意义(P<0.05)。结论艾司西酞普兰治疗门诊抑郁症患者的效果较舍曲林更优,能够减少不良反应,提升治疗安全性。

Objective To compare the different effects of escitalopram and sertraline in the treatment of outpatients with depression.Methods From January 2016 to April 2017,84 patients with depression were analyzed retrospectively.42 patients were treated with Escitalopram in the observation group,and 42 patients were treated with Sertraline in the control group.The clinical effects of the two groups were compared.Results The total effective rate was 83.33%in the observation group,and 54.76%in the control group,and the difference was statistically significant(P<0.05);the HAMD score was(13.26±2.15)in the observation group,and(20.59±2.64)in the control group after 8 weeks,and the difference was statistically significant(P<0.05);the incidence of adverse reactions was 7.14%in the observation group and 26.19%in the control group,and the difference was statistically significant(P<0.05).Conclusion Escitalopram is more effective than Sertraline in the treatment of outpatients with depression,which can reduce adverse reactions,improve the safety of treatment,and can be popularized in clinical practice.