大动脉粥样硬化性卒中的中医体质分布与Hcy的相关性研究

Correlation study of TCM constitution distribution with Hcy contents of large artery atherosclerosis patients

目的探究大动脉粥样硬化性卒中(LAA)的中医体质分布与同型半胱氨酸(Hcy)的相关性。方法研究对象为2018年2月~2019年8月收治的100例LAA患者,调查中医体质分类,测定Hcy,探讨Hcy与LAA的中医体质分布的相关性。结果研究对象中以血瘀质的患者最多,其次为痰湿质、阴虚质,但不同体质Hcy指标无显著差异(P>0.05),通过相关性分析,阴虚质、痰湿质、血瘀质是导致LAA的危险因素,Logistic回归分析,Hcy相应的OR值>1,表明Hcy是患LAA的危险因素,两者存在显著差异,Hcy与LAA是正相关(P>0.05)。结论LAA的发生与痰湿质、瘀血质、阴虚质、Hcy有关,虽未发现LAA患者的中医体质和Hcy有关,但检定Hcy可帮助临床诊断LAA。

Objective To explore the correlation of TCM constitution distribution with Hcy(homocysteine)contents of large artery atherosclerosis(LAA)patients.Methods 100 LAA patients treated from February 2018 toAugust 2019 in our hospital were investigated.TCM constitutions and Hcy contents and its mutual relationships were expounded.Results Most of patients had blood stasis,followed by phlegm dampness and yin deficiency.Hcy contents among different TCM constitution patients were not significantly different(P>0.05).Correlation analysis showed that risk factors of LAA included yin deficiency,phlegm dampness and blood stasis.According to Logistic regression analysis,OR value of Hcy was larger than 1,demonstrating that risk factors of LAA were Hcy contents;in other words,Hcy contents were positively related to LAA.Conclusion The occurrence of LAA is related to phlegm dampness,blood stasis and yin deficiency.Although the relationship between TCM constitutions and Hcy contents of LAA patients has not been proved,the detection of Hcy is beneficial to diagnosis of LAA.