早期结直肠癌组织中PGC-1α、NF-κB p65的表达及与临床病理特征和预后的相关性分析

Expression of PGC-1αand NF-κB p65 in the Diseased Tissue of Early Colorectal Cancer and Its Correlation with Clinicopathological Characteristics and Prognosis

目的探讨早期结直肠癌组织中过氧化物酶体增殖物受体共激活因子-1α(peroxisome proliferator ivated receptorγcoactivator-1α,PGC-1α)、核因子-κB(nuclear factor-κB,NF-κB)p65的表达情况及与临床病理特征和预后的相关性。方法选取2015年11月-2017年11月收治的75例结直肠癌患者作为研究对象,对其癌组织及癌旁组织进行染色。检测组织中PGC-1α及NF-κB p65的表达水平,并结合2组结直肠黏膜组织病理分期情况,分析PGC-1α、NF-κB p65的表达与病理特征的相关性,随访2年,观察预后情况。结果癌组织中NF-κB p65、PGC-1α高表达率高于癌旁组织(P<0.05);TNMⅢ~Ⅳ期、存在血管侵犯、伴随淋巴结转移、肿瘤低分化的结直肠癌患者NF-κB p65、PGC-1α的表达水平更高(P<0.05)。NF-κB p65、PGC-1α的表达与结直肠癌患者TNM分期、淋巴结转移、血管侵犯程度呈正相关,与肿瘤分化程度呈负相关(P<0.01);二者表达水平与结直肠癌患者生存率无相关性(P>0.05)。结论结直肠癌NF-κB p65、PGC-1α的表达与疾病严重程度具有相关性,其表达水平越高,患者病情越严重。

Objective To investigate the expression of peroxisome proliferator-activated receptorγcoactivator-1α(PGC-1α)and nuclear factor-κB(NF-κB)p65 in the diseased tissue of early colorectal cancer(CRC),and its correlation with clinicopathological characteristics and prognosis.Methods Seventy-five patients with CRC treated from November 2015 to November 2017 were selected as the research subjects.The cancer tissues and adjacent tissues were stained.The expression levels of PGC-1αand NF-κB p65 in the tissues were detected,the correlation between the pathological stages of colorectal mucosal tissues in each group was analyzed,and the correlation between the expression of PGC-1α,NF-κB p65 and pathological characteristics was analyzed.They were followed up for two years to observe the prognosis.Results The high expression rate of NF-κB p65 and PGC-1αin cancer tissues was significantly higher than that in normal adjacent tissues(P<0.05).The expressions of NF-κB p65 and PGC-1αwere significantly higher in CRC patients who hadⅢ-Ⅳstages of TNM stages,vascular invasion,lymph node metastasis,and poorly differentiated tumour(P<0.05).The expressions of NF-κB p65 and PGC-1αwere positively correlated with TNM stage,lymph node metastasis and vascular invasion in CRC patients,and negatively correlated with tumor differentiation(P<0.01).The difference in expression between the two has no correlation with the survival rate of CRC patients(P>0.05).Conclusion The expression of NF-κB p65 and PGC-1αin patients with CRC is related to the severity of the disease.The higher the expression levels of NF-κB p65 and PGC-1α,the more severe the patient's condition is.