多模态MRI联合超声显微手术治疗脑胶质瘤临床疗效及预后分析

Clinical Effect and Prognosis of Multimodal MRI Combined with Ultrasound Microsurgery on Brain Glioma

目的探讨多模态核磁共振成像(MRI)联合超声显微手术治疗脑胶质瘤(BG)临床疗效,并分析其预后情况。方法回顾性分析2014年1月-2017年8月收治的68例BG患者的临床病理资料,选取行超声显微手术的32例作为对照组,选取行多模态MRI联合超声显微手术的36例作为观察组,比较2组手术切除范围、术前和出院时卡氏功能状态(KPS)评分、术后1周内并发症情况及术后随访2年内病死率和复发率、癫痫控制情况。结果观察组手术全切除率高于对照组,出院时KPS评分高于对照组(P<0.05)。术后1周内,观察组并发症发生率低于对照组(P<0.05)。术后2年,观察组病死率和复发率低于对照组,癫痫控制情况优于对照组(P<0.05,P<0.01)。结论多模态MRI联合超声显微手术治疗BG可以提高手术全切除率和患者生存质量,降低病死率和复发率,有效控制癫痫的发生,降低并发症发生率。

Objective To explore clinical effect of multimodal magnetic resonance imaging(MRI)combined with ultrasound microsurgery on brain glioma(BG),and to analyze the prognosis.Methods The clinicopathological data of 68 BG patients who were admitted to the hospital from January 2014 to August 2017 were retrospectively analyzed.Thirty-two patients who underwent ultrasound microsurgery were enrolled as control group,while 36 patients who underwent multimodal MRI combined with ultrasound microsurgery were enrolled as observation group.The scope of surgical resection,scores of Karnofsky performance status(KPS)before surgery and at discharge,complications within 1 week after surgery,death and recurrence rate within 2 years after surgery,and epilepsy control were compared between the two groups.Results The total resection rate of observation group was significantly higher than that of control group,and KPS score of observation group at discharge was significantly higher than that of control group(P<0.05).Within 1 week after surgery,incidence of complications in observation group was significantly lower than that in control group(P<0.05).At 2 years after surgery,death and recurrence rates of observation group were significantly lower than those of control group,and epilepsy control was better than that in the control group(P<0.05,P<0.01).Conclusion Multimodal MRI combined with ultrasound microsurgery in the treatment of BG can improve total resection rate and quality of life,reduce death and recurrence rate,effectively control occurrence of epilepsy,and reduce incidence of complications.