比索洛尔联合参麦注射液治疗老年慢性心力衰竭的临床效果及对生活质量的影响

Clinical Effect of Bisoprolol Combined with Shenmai Injection in the Treatment of Chronic Heart Failure in the Elderly and Its Influence on the Quality of Life

目的探讨比索洛尔联合参麦注射液治疗老年慢性心力衰竭的临床效果及对生活质量的影响。方法选取2018年3月-2019年3月收治的老年慢性心力衰竭93例,据治疗方法的不同分为观察组47例和对照组46例。对照组在常规治疗基础上加用比索洛尔治疗,观察组在对照组基础上加用参麦注射液治疗,2组疗程均为半年。比较2组临床疗效,治疗前后心功能指标[左心室收缩末期内径(LVESD)、左心室舒张末期内径(LVEDD)、左心室射血分数(LVEF)]改善情况血浆脑钠肽(BNP)、肌钙蛋白Ⅰ(cTnⅠ)变化情况,生活质量改善情况以及治疗期间不良反应发生情况。结果观察组治疗总有效率高于对照组(P<0.05)。2组治疗后LVESD、LVEDD、LVEF、BNP、cTnⅠ、明尼达心力衰竭生活质量调查表(LiHFe)评分均较治疗前改善,且观察组改善程度均大于对照组(P<0.05)。2组治疗期间不良反应总发生率比较差异无统计学意义(P>0.05)。结论比索洛尔联合参麦注射液治疗老年慢性心力衰竭效果确切,可有效改善患者心功能,降低BNP、cTnⅠ水平,提高患者生活质量且具有良好的安全性。

Objective To explore the clinical effect of Bisoprolol combined with Shenmai injection in the treatment of chronic heart failure( CHF) in the elderly and its impact on the quality of life. Methods A total of 93 elderly patients with CHF admitted from March 2018 to March 2019 were selected as the research subjects. According to the different treatment methods,they were divided into observation group( n = 47) and control group( n = 46). The control group was treated with Bisoprolol on the basis of conventional treatment,and the observation group was supplemented with Shenmai injection on the basis of the control group. The course of treatment in both groups was six months. The clinical efficacy and the improvement of cardiac function indexes [left ventricular end systolic diameter( LVESD),left ventricular end diastolic diameter( LVEDD),left ventricular ejection fraction( LVEF) ] before and after treatment were compared. The changes of plasma brain natriuretic peptide( BNP),troponin Ⅰ( cTn Ⅰ),the improvement of quality of life and the occurrence of adverse reactions during treatment were compared. Results The total effective rate of the observation group was significantly higher than that of the control group( P < 0. 05). After treatment,the LVESD,LVEDD,LVEF,BNP,cTnⅠ,and Li HFe scores of the two groups were all improved compared with those before treatment,and the improvement of the observation group was greater than that of the control group( P < 0. 05). There was no statistical significance in the total incidence of adverse reactions between the two groups during the treatment( P > 0. 05). Conclusion Bisoprolol combined with Shenmai injection is effective in the treatment of CHF in the elderly. It can effectively improve the heart function,reduce the BNP and c Tn I levels,improve the quality of life of the patients,and has good safety.