经皮吸收制剂三七膜剂的制备工艺研究

Research on the Preparation Process of Percutaneous Absorption Preparation Sanqi Coating Agents

目的:考察经皮吸收制剂三七膜剂的制备工艺。方法:用聚乙烯醇05-88与聚乙烯醇17-88作为成膜材料,甘油作为增塑剂,吐温80作为表面活性剂在单因素实验的基础上用正交实验L9(33)进行基质处方的筛选,考察制成膜剂的柔软性、光滑性、色泽透明度、均匀性,最后得出最佳基质处方比例。结果:经筛选得出的最佳基质处方为:PVA05-881.0 g,PVA17-883.0 g,甘油4.0 g,吐温802.0 g。结论:通过正交实验筛选所得的基质中加入三七提取物后其柔软性、光滑性、色泽透明度、均匀性较好;该三七膜剂的制备工艺简单、可行。

Objective:To survey the preparation process of percutaneous absorption preparation Sanqi(notoginseng radix et rhizoma)coating agents.Methods:Polyvinyl alcohol 05-88 and polyvinyl alcohol 17-88 as the coating forming materials,glycerol as plasticizer and polysorbate80 as surface active agent were used to screen the matrixprescription by orthogonal test L9(33)on the foundation of single-factor test,to investigate the softness,smoothness,color transparency and uniformity of the coating agents,and finally to obtain the best matrix prescription ratio.Results:The best matrix prescription through screening were:PVA05-881.0 g,PVA17-883.0 g,glycerol 4.0 g and polysorbate 802.0 g.Conclusion:The matrix obtained and screened by orthogonal test L9(33)show better softness,smoothness,color transparency and uniformity and others after adding Sanqi extracts,the preparation process of Sanqi coating agents are simple and feasible.