CYP1A1基因多态性与特发性男性不育的相关性研究进展

Advances in the relationship between CYP1A1 gene polymorphism and idiopathic male infertility

细胞色素P450(CYP)为一类结构和功能相关的超家族基因编码的同工酶,它参与内源性物质和外源性物质的代谢。CYP1A1是CYP的亚族,位于染色体15q22-qter上,是一种底物诱导型微粒体酶,参与多环芳烃(PAHs)和芳香胺的I相代谢。它的基因多态性将可能会影响外源性物质的代谢,增加DNA加合物的形成,而在精子细胞中,DNA加合物的出现预示着DNA受损,可能会影响精子细胞的有丝分裂,从而造成不育。随着DNA测序的发展,研究CYP1A1基因多态性与特发性男性不育的相关性成了研究热点,许多研究表明CYP1A1基因多态性可能是特发性男性不育的一个危险因素。本文综述了CYP1A1基因多态性与特发性男性不育的研究进展。

Cytochrome P450(CYP)is a class of isoenzymes encoded by structural and functional superfamily genes involved in the metabolism of endogenous and exogenous substances.CYP1 A1,a subfamily of CYP,located on chromosome 15 q22-qter,is a substrate-inducing microsomal enzyme involved in the phase I metabolism of polycyclic aromatic hydrocarbons(PAHs)and aromatic amines.Its genetic polymorphism may affect the metabolism of exogenous substances and increase the formation of DNA adducts.In sperm cells,the appearance of DNA adducts indicates DNA damage,which may affect sperm cell mitosis,resulting into infertility.With the development of DNA sequencing,the study of the relationship between CYP 1 A1 gene polymorphism and idiopathic male infertility has become a research hotspot.Many studies have shown that CYP1 A1 gene polymorphism may be a risk factor for idiopathic male infertility.This article reviews the research progress of CYP1 A1 gene polymorphism and idiopathic male infertility.