2-甲氧基雌二醇氯仿溶剂化物脱溶剂动力学研究

Research of desolvent kinetics of 2-methoxyestradiol chloroform solvate

在2-甲氧基雌二醇氯仿溶剂化物(2-ME.2CHCl3)制备和单晶X-射线衍射法进行结构确证的基础上,采用等温脱溶剂法和非等温脱溶剂法,进行2-ME.2CHCl3脱溶剂动力学规律研究.2-ME.2CHCl3等温脱溶剂过程的脱溶剂机理最适模型为R3,即几何边界层模型;其非等温脱溶剂过程的脱溶剂机理,在升温速率为5 K/min以下时,最适合模型为R3,在升温速率为10 K/min^20 K/min时,最适合模型为R2,属于相界面反应机理,控制步骤是相界面的推进.2-ME为进入临床研究的具有抗肿瘤作用的药物,其溶剂化物脱溶剂动力学研究,可以为其制剂研究提供重要的依据.

The desolvation kinetics of 2-ME.2CHCl3 was studied by isothermal desolvation method and non isothermal desolvation method based on the preparation of 2-ME.2CHCl3 and the structural identification by single crystal X-ray diffraction.For the isothermal desolvent process of 2-ME.2CHCl3,the best desolvent mechanism model is R3,i.e.geometric boundary layer model.For the nonisothermal desolvent process of 2-ME.2CHCl3,when the heating rate is below 5K/min,the most suitable model is R3,and when the heating rate is 10 K/min^20 k/min,the most suitable model is R2.R2 model belongs to the phase interface reaction mechanism which control step is the promotion of phase interface.2-ME is an anti-tumor drug entered clinical studies,the study on the desolvent kinetics of its solvate can provide an important basis for its pharmaceutical preparation.