胃癌中表皮生长因子受体2蛋白表达与临床病理特征的关系

Relationship Between Epidermal Growth Factor Receptor 2 Protein Expression and Clinicopathological Characteristics in Gastric Cancer

目的探讨HER2蛋白的表达与胃癌临床病理特征的关系。方法选取2019年7月~2020年1月我院手术切除的201例胃癌标本的病理资料,均进行免疫组化(IHC)法与原位荧光杂交技术(FISH)检测,并分析不同临床病理特征HER2过表达情况。结果共201例标本中,IHC 3+18例,IHC 2+39例,对IHC 2+标本进一步行FISH检测,发现有5例存在突变。IHC 1+56例,IHC 0+88例,共有23例存在HER2过表达。近端胃癌中HER2过表达率高于中远端胃癌,肠型胃癌HER2过表达率高于混合型和弥漫型胃癌,高中分化胃癌HER2过表达率高于低分化胃癌,差异有统计学意义(P<0.05);淋巴结是否转移中HER2过表达率比较,差异无统计学意义(P>0.05)。结论HER2蛋白在近端胃癌中的表达高于中远端胃癌,并且HER2蛋白的表达与Lauren分型和组织学分化有关,与淋巴结是否转移无关。

Objective To explore the relationship between HER2 protein expression and clinicopathological characteristics of gastric cancer.Methods From July 2019 to January 2020,the pathological data of 201 gastric cancer specimens that were surgically removed in our hospital were detected by immunohistochemistry(IHC)and in situ fluorescence hybridization(FISH),and different clinicopathological features were analyzed HER2 overexpression.Results A total of 201 specimens,IHC 3+18 cases,IHC 2+39 cases,further FISH testing of IHC 2+ specimens,5 cases were found to have mutations.IHC 1+56 cases,IHC 0+88 cases,a total of 23 cases had HER2 overexpression.The overexpression rate of HER2 in proximal gastric cancer is higher than that in middle and distal gastric cancer,the overexpression rate of HER2 in intestinal gastric cancer is higher than that of mixed and diffuse gastric cancer,and the overexpression rate of HER2 in high-differentiated gastric cancer is higher than that in low-differentiated gastric cancer,the difference was statistically significant(P<0.05);there was no statistically significant difference in the HER2 overexpression rate in lymph node metastasis(P>0.05).Conclusion The expression of HER2 protein in proximal gastric cancer is higher than that in middle and distal gastric cancer,and the expression of HER2 protein is related to Lauren typing and histological differentiation,and has nothing to do with lymph node metastasis.