藏族高龄孕产妇妊娠结局及围产儿结局的临床分析

Pregnancy and Perinatal Outcome of Pregnant Tibetan Women at Advanced Age

目的研究藏族单胎高龄孕产妇的妊娠结局及围产儿结局。方法选取2019年1月至2019年12月西藏自治区人民医院妇产科1521例单胎孕产妇资料,根据年龄分为18~34岁(适龄组)、35~39岁(高龄组)和≥40岁(超高龄组),回顾性分析各组妊娠结局及围产儿结局。结果与适龄组相比,高龄组和超高龄组的妊娠期高血压疾病、胎盘早剥、胎死宫内的发生率显著升高(P <0. 05);高龄组的剖宫产率显著升高(P <0. 001);超高龄组的胎儿畸形率明显升高(P=0. 013)。与高龄组相比,超高龄组的胎儿畸形及胎死宫内的发生率更高(P <0. 05)。结论藏族高龄孕产妇相较适龄孕产妇不良妊娠结局及不良围产儿结局的风险会进一步升高。

Objective To make a clinical study on pregnancy and perinatal outcome of pregnant Tibetan women at advanced maternal age.Methods The clinical data of 1521 pregnant Tibetan women with single fetus hospitalized during the period from January,2019 to December,2019 were collected;the women were divided into 3 groups based on age:maternity age group(MA group,18 to 34 years old),advanced maternal age group(AMA group,35 to 39 years old)and the over-advanced maternal age group(OAMA group,over than 40 years old);the pregnancy and perinatal outcome of the women in each group were retrospectively analyzed.Results The occurrence of gestational hypertension,placental abruption and intrauterine fetal death in advanced group and super-advanced group were much higher than that in normal group(P<0.05);the rate of cesarean section was significantly higher in AMA group than that in MA group(P<0.001);the rate of fetal malformation in OAMA group was significantly higher than that in MA group(P=0.013);the rates of fetal malformation and intrauterine fetal death was significantly higher in the OAMA group than those in AMA group(P<0.05).Conclusions The risks of adverse pregnancy outcome and adverse perinatal outcome are significantly higher in pregnant Tibetan women at advanced maternal age than those at maternal age.