肝功能、凝血因子及血常规检测在肺癌诊断与治疗中的应用价值

Application value of liver function,coagulation factors and blood routine test in diagnosis and treatment of lung cancer

目的探讨肝功能、凝血因子及血常规检测在肺癌诊断与治疗中的临床应用价值。方法选择2018年6月至2019年5月在解放军总医院确诊且尚未治疗的肺癌患者98例和健康对照者205例,对两组研究对象的肝功能(碱性磷酸酶、谷氨酰转肽酶、乳酸脱氢酶、总蛋白、清蛋白、丙氨酸氨基转移酶、天门冬氨酸氨基转移酶、总胆红素、直接胆红素)、凝血因子(凝血酶原时间、活化部分凝血活酶时间、凝血酶时间、纤维蛋白原、D-二聚体)及血常规(红细胞计数、白细胞计数、血红蛋白、血小板计数)结果进行回顾性分析。结果肺癌组患者血清清蛋白水平显著低于健康对照组(P<0.05),碱性磷酸酶、谷氨酰转肽酶、乳酸脱氢酶、活化部分凝血活酶时间、血浆纤维蛋白原、D-二聚体、白细胞计数、血小板计数水平显著高于健康对照组(P<0.05),以上指标水平的差异与肺癌病理分型无关(P>0.05)。肺癌组中,清蛋白水平下降患者碱性磷酸酶、谷氨酰转肽酶、血浆纤维蛋白原、D-二聚体水平显著高于清蛋白水平正常患者。结论在肺癌诊断与治疗过程中进行肝功能、凝血因子及血常规检测可及时判断患者的营养状态、血液高凝状况,有助于后续治疗。

Objective To explore the clinical application value of liver function,coagulation factors and blood routine test in the diagnosis and treatment of lung cancer.Methods Ninety-eight untreated patients with lung cancer and 205 healthy controls in General Hospital of PLA from June 2018 to May 2019 were selected.The results of liver function(alkaline phosphatase,glutamyltransferase,lactate dehydrogenase,total protein,albumin,glutaminotransferase,aspartate aminortransferase,total bilirubin,direct bilirubin),coagulation factors(thromboplastin time,activated partial thromboplastin time,thrombin time,fibrinogen,D-dimer)and blood routine(RBC count,WBC count,Hb,PLT count)were retrospectively analyzed.Results Serum albumin level in the patients with lung cancer was significantly lower than that in the healthy control group(P<0.05),alkaline phosphatase,glutamyltransferase,lactate dehydrogenase,activated partial thromboplastin time,fibrinogen,D-dimer,WBC count and PLT count were significantly higher than those in the healthy control group(P<0.05).The differences of above indicators had no relation with the lung cancer pathological classification(P>0.05).In the lung cancer group,the levels of alkaline phosphatase,glutamyltransferase,plasma fibrinogen,D-dimer in the patients with decreased albumin were significantly higher than those in the patients with normal albumin.Conclusion In the process of diagnosis and treatment of lung cancer,the detection of liver function,coagulation factors and blood routine test can timely judge the status of nutrition and blood hypercoagulability in the patients,which is helpful for follow-up treatment.