他汀类药物联合抗血小板聚集药物治疗缺血性脑血管病的临床效果

Clinical effect of statins combined with antiplatelet aggregation drugs on ischemic cerebrovascular disease

目的研究他汀类药物联合抗血小板聚集药物治疗缺血性脑血管病的临床效果。方法选取我院2016年8月至2019年7月收治的122例缺血性脑血管病患者作为研究对象,按照随机数字表法将其分为对照组(61例)与观察组(61例),对照组在常规治疗的基础上进行抗栓治疗,观察组在对照组基础上联合瑞舒伐他汀治疗。比较两组的总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)水平、神经功能缺损程度、日常生活活动能力、临床治疗效果及缺血性脑梗阻发生情况。结果治疗后,两组的TC、TG、LDL-C水平均降低,HDL-C水平均升高,且观察组优于对照组(P<0.05)。治疗后,两组的SSS、Barthel指数评分均升高,且观察组高于对照组(P<0.05)。观察组的临床治疗总有效率高于对照组(P<0.05)。观察组的缺血性脑梗阻发生率低于对照组(P<0.05)。结论他汀类药物联合抗血小板聚集药物治疗缺血性脑血管病可调节血脂水平,抑制血栓形成,有助于降低缺血性脑梗阻发生率,且可促进患者神经功能以及日常生活活动能力的恢复。

Objective To study the clinical effect of statins combined with antiplatelet aggregation drugs on ischemic cerebrovascular disease.Methods A total of 122 patients with ischemic cerebrovascular disease treated in our hospital from August 2016 to July 2019 were selected as the research objects and divided into control group(61 cases)and observation group(61 cases)according to the random number table method.The control group received antithrombotic therapy on the basis of conventional treatment,and the observation group received rosuvastatin treatment on the basis of the control group.The levels of total cholesterol(TC),triglyceride(TG),high-density lipoprotein cholesterol(HDL-C)and low-density lipoprotein cholesterol(LDL-C),the degree of neurological impairment,the ability of daily activities,the clinical effect and the incidence of ischemic cerebral obstruction were compared between the two groups.Results After treatment,the levels of TC,TG and LDL-C in both groups decreased,the level of HDL-C increased,and those in the observation group were better than the control group(P<0.05).After treatment,SSS and Barthel index scores in both groups increased,and those in the observation group were higher than the control group(P<0.05).The total effective rate of clinical treatment in the observation group was higher than that in the control group(P<0.05).The incidence of ischemic cerebral obstruction in the observation group was lower than that in the control group(P<0.05).Conclusion Statins combined with antiplatelet aggregation drugs in the treatment of ischemic cerebrovascular disease can regulate blood lipid level,inhibit thrombosis,help to reduce the incidence of ischemic cerebral obstruction,and promote the recovery of patients'neurological function and daily activity.