不同剂量阿托伐他汀短期治疗急性冠脉综合征患者的临床效果

Clinical effect of short-term treatment with different doses of atorvastatin in patients with acute coronary syndrome

目的分析不同剂量阿托伐他汀短期治疗急性冠脉综合征患者的临床效果。方法选择2016年11月至2017年11月我院收治的104例急性冠脉综合征患者为研究对象,将其按照治疗方法的不同分为参照组和高剂量组,各52例。参照组采用常规剂量阿托伐他汀(20 mg/d)治疗,高剂量组采用高剂量阿托伐他汀(40 mg/d)治疗。比较两组治疗前、后血脂指标水平、血清hs-CRP、MMP-9水平、APACHEⅡ评分、治疗效果及不良反应发生情况。结果治疗后,两组的TG、TC水平均降低,且高剂量组低于参照组(P<0.05)。治疗后,两组的血清hs-CRP和MMP-9水平均降低,且高剂量组低于参照组(P<0.05)。治疗后,两组的APACHEⅡ评分均降低,且高剂量组低于参照组(P<0.05)。高剂量组的治疗总有效率显著高于参照组(P<0.05)。两组的不良反应总发生率比较,差异不具有统计学意义(P>0.05)。结论相比于20 mg/d,40 mg/d阿托伐他汀短期治疗急性冠脉综合征患者的效果更加显著,且安全性好,值得临床推广应用。

Objective To analyze the clinical effect of short-term treatment with different doses of atorvastatin in patients with acute coronary syndrome.Methods A total of 104 patients with acute coronary syndrome admitted in our hospital from November 2016 to November 2017 were selected as the research objects,and the patients were divided into reference group and high-dose group according to different treatment methods,with 52 cases in each group.The reference group was treated with conventional dose atorvastatin(20 mg/d),and the high-dose group was treated with high-dose atorvastatin(40 mg/d).The blood lipid index,serum hs-CRP and MMP-9 levels,APACHEⅡscore before and after treatment,treatment effect and adverse reactions were compared between the two groups.Results After treatment,the TG and TC levels of the two groups decreased,and those in the high-dose group were lower than the reference group(P<0.05).After treatment,the levels of serum hs-CRP and MMP-9 in the two groups decreased,and those in the high-dose group were lower than the reference group(P<0.05).After treatment,the APACHEⅡscore of both groups decreased,and that in the high-dose group was lower than the reference group(P<0.05).The total effective rate of treatment in the high-dose group was significantly higher than that in the reference group(P<0.05).There was no significant difference in the total incidences of adverse reactions between the two groups(P>0.05).Conclusion Compared with 20 mg/d,40 mg/d atorvastatin is more effective in short-term treatment of patients with acute coronary syndrome,and it has good safety and is worthy of clinical promotion and application.