摘要
以氯代特戊酰氯、盐酸羟胺和邻氯苄氯为主要原料,经酰化反应、成环反应、缩合反应得到粗品异噁草酮,再经氯化氢气体处理和异丙醇/石油醚重结晶,制备得到高品质异噁草酮原药,含量超过98.0%。此方法具有工艺条件温和、易操作、含量高等优点,适合大规模工业化生产。
The crude product of clomazone was synthesized using chlorotervaloyl chloride, hydroxylamine hydrochloride and 2-chlorobenzyl chloride as raw materials through a series ractions including oximation, cyclization and condensation. Clomazone with a purity of more than 98.0% was obtained by purifying the crude product with HCl gas and recrystallization from iso-propyl alcohol/petroleum ether. This method was suitable for large-scale industrial production with many advantages such as mild reaction conditions, simple operation, high quality. etc.
作者
程超
欧阳宇迪
兰世林
刘源
熊莉莉
陈郭芹
徐健
CHENG Chao;OUYANG Yu-di;LANShi-lin;LIU Yuan;XIONG Li-li;CHEN Guo-qin;XU Jian(Hunan Research Institute of Chemical Industry Co.,Ltd.,Nation Engineering Research Center for Agrochemicals,Changsha 410014,China;Hunan Province Key Laboratory for Agrochemicals,Changsha 410014,China;Hunan Haili Changde Pesticide&Chemicals Co.,Ltd.,Changde 415001,China)
出处
《精细化工中间体》
CAS
2020年第2期22-25,共4页
Fine Chemical Intermediates
基金
国家重点研发计划项目(2017YFB0307200)。
关键词
异噁草酮
氯代特戊酰氯
高品质
重结晶
clomazone
chlorotervaloyl chloride
high quality
recrystallization
