摘要
改进了一类甾体22-羧酸乙酯化合物的合成,以去氢表雄酮为原料,经过3步反应得到产物,优化条件下总收率69%。该工艺避免了复杂的柱层析纯化过程,具有工业化生产前景。
A series of steroid 22-carboxylic acid ethyl ester compounds were obtained with a total yield of 69%through a three-step reaction using dehydroepiandrosterone as the starting material. This process can avoid the complicated purification process of column chromatography and has been industrialized.
作者
陈文霞
金家华
吕永辉
王涛
沈大冬
CHEN Wen-xia;JIN Jia-hua;LV Yong-hui;WANG Tao;SHEN Da-dong(Zhejiang Medicine Co.,Ltd.,Xinchang Pharmaceutical Factory,Shaoxing 312500,China;College of Pharmaceutical Science,Zhejiang University of Technology,Hangzhou 310032,China)
出处
《精细化工中间体》
CAS
2020年第2期34-36,40,共4页
Fine Chemical Intermediates
关键词
甾体22-羧酸乙酯化合物
去氢表雄酮
不对称氢化
steroid 22-carboxylic acid ethyl ester compounds
dehydroepiandrosterone
asymmetric hydrogenation
