授精次数对自然周期供精人工授精妊娠结局影响的探究与评价

Pregnancy outcome of artificial insemination by donor during natural cycles as related to number of insemination

目的探究与评价授精次数对自然周期供精人工授精妊娠结局的影响。方法对2009年11月至2019年6月实施的2 052个自然周期供精人工授精妊娠结局进行了回顾性统计、分析。结果排卵前、后双次授精的活产率略高于排卵后单次授精,流产率(尤其早期流产率)稍低于单次授精,但差异无统计学意义(P>0.05)。两者的临床妊娠率基本一致。结论对于自然周期供精人工授精而言,只要所用精液数量、质量一致,能较好地把控授精时机,不论排卵前、后双次授精或排卵后单次授精,都可获得一致的临床妊娠率,可根据患者的具体情况灵活调整。

Objective To determine the impacts of the number of insemination on pregnancy outcome of artificial insemination by donor(AID) during natural cycles. Methods A retrospective statistic analysis was performed of the pregnancy outcomes of AID during 2 052 natural cycles between November 2009 and June 2019. Results Compared with single AID, dual AID immediately before and after ovulation resulted in modestly higher live birth rate and lower miscarriage rate(early miscarriage in particular), but the difference was not statistically significant( P>0.05). The clinical pregnancy rates of the two AID approaches were largely comparable. Conclusion For AID during natural cycles, either single AID or dual AID immediately before and after ovulation may lead to similar rates of clinical pregnancy, given comparable amount and quality of the semen used, and well controlled timing of the insemination.Proper decision to use single or dual AID could be made on a case-by-case basis.