基于迈克尔加成构筑聚丁二烯三嵌段共聚物

Synthesis of polybutadiene based triblock copolymer via Michael addition reaction

以端羟基聚丁二烯(HTPB)及甲氧基聚乙二醇胺(mPEG-NH2)为原料,依次通过酰化、迈克尔加成反应制备出了聚乙二醇单甲醚-聚丁二烯-聚乙二醇单甲醚(mPEG-b-PB-b-mPEG)三嵌段共聚物.通过红外光谱(FTIR)、核磁共振氢谱(1H-NMR)、碳谱(13C-NMR)证明合成产物与设计一致;通过热重分析仪(TGA)对HTPB、mPEG-NH2、mPEG-b-PB-b-mPEG热性能进行对比,表明mPEG-b-PB-b-mPEG具有较好的热稳定性;通过动态光散射粒度分析仪(DLS)及透射电子显微镜(TEM)对mPEG-b-PB-b-mPEG组装特性进行了研究,结果表明mPEG-b-PB-b-mPEG在水溶液中可形成稳定分布的点状胶束.

mPEG-b-PB-b-mPEG triblock copolymer was synthesized via combination of acylation and Michael addition reaction by using hydroxyl terminated polybutadiene(HTPB)and methoxypolyethylene glycol amine(mPEG-NH2)as raw materials.The infrared spectroscopy(FTIR),nuclear magnetic resonance spectroscopy(1H-NMR),and carbon spectrum(13C-NMR)were employed to identify the structure of synthesized product,and the results confirmed that the structure was consistent with the design.The thermal properties of HTPB,mPEG-NH2 and mPEG-b-PB-b-mPEG were compared by thermogravimetric analyzer(TGA)tests,and the results revealed that mPEG-b-PB-b-mPEG exhibit good thermal stability.As a novel amphiphilic block copolymer,the assembly behavior of mPEG-b-PB-b-mPEG in aqueous solution was also evaluated by Dynamic light scattering particle size analyzer(DLS)and transmission electron microscopy(TEM).The results suggest that mPEG-b-PB-b-mPEG can formed a well-defined dot micelle in aqueous solution.