CD56、CK19、Galectin-3和TPO的联合检测在甲状腺乳头状癌中的应用

Application of Combined Detection of CD56,CK19,Galectin-3 and TPO in Papillary Thyroid Carcinoma

目的探讨和分析CD56、CK19、Galectin-3和TPO的联合检测在甲状腺乳头状癌中的诊断价值。方法选择2018年10月—2019年9月期间本院收治497例甲状腺切除术患者的病理标本作为研究对象,切取的甲状腺组织标本均行免疫组织化学染色,检测CD56、CK19、Galectin-3和TPO的表达,分析这四种标记物的联合检测在甲状腺乳头状癌中的诊断价值。结果CD56、CK19、Galectin-3和TPO表达在103例甲状腺乳头状癌中的阳性率分别为1.94%、92.23%、96.12%和11.65%,在394例良性甲状腺肿瘤中的阳性率分别为86.55%、57.36%、16.75%和82.74%,其组间差异均存在统计学意义(P<0.05)。单项检测中CD56的灵敏度最高,CD56的特异度最高;而四项串联联合检测甲状腺乳头状癌诊断的灵敏度、特异度和准确度均高于各项单项检测。结论CD56、CK19、Galectin-3和TPO可作为甲状腺乳头状癌的有效指标,联合检测诊断是可提高其诊断的灵敏度、特异度和准确度。

Objective To explore and analyze the diagnostic value of combined detection of CD56,CK19,galectin-3 and TPO in thyroid papillary carcinoma.Methods The pathological specimens of 497 patients with thyroidectomy admitted to our hospital from October 2018 to September 2019 were selected as the study objects.All the thyroid tissue samples were stained by immunohistochemistry.Expressions of CD56,CK19,galectin-3 and TPO were detected,and the diagnostic value of the combined detection of these four markers in thyroid papillary carcinoma was analyzed.Results The positive rates of CD56,CK19,Galectin-3 and TPO expression in 103 cases of papillary thyroid carcinoma were 1.94%,92.23%,96.12%,and 11.65%,respectively,while the positive rates in 394 cases of benign thyroid tumor were 86.55%,57.36%,16.75% and 82.74%,respectively.The differences between the groups were statistically significant(P<0.05).The sensitivity of CD56 was the highest,and the specificity of CD56 was the highest.The sensitivity,specificity and accuracy of the four tandem tests for diagnosis of papillary thyroid carcinoma were higher than those of the single tests.Conclusion CD56,CK19,galectin-3 and TPO can be used as effective indicators of thyroid papillary carcinoma,and joint detection and diagnosis can improve the sensitivity,specificity and accuracy of its diagnosis.