血清可溶性生长刺激表达基因2蛋白、白介素-17在经皮冠状动脉介入治疗急性非ST段抬高型心肌梗死患者预后评估中的价值研究

The value of serum soluble ST2 and IL-17 in prognostic evaluation of patients with NSTEMI treated with PCI

目的探讨可溶性生长刺激表达基因2蛋白(sST2)、白介素-17(IL-17)在行经皮冠状动脉介入治疗(PCI)治疗急性非ST段抬高型心肌梗死(NSTEMI)患者预后中的评估价值。方法我院收治的80例NSTEMI患者,依据是否发生不良心血管事件分为预后良好组和预后差组,分析PCI治疗NSTEMI患者预后的影响因素及血清sST2、IL-17水平在PCI治疗NSTEMI患者预后中的评估价值。结果预后良好组与预后差组性别、年龄、吸烟史、基础疾病类型、合并感染病变血管分类比较,差异无统计学意义(P>0.05),预后良好组血清总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、sST2、IL-17水平低于预后差组(P<0.05)。sST2、IL-17水平是PCI治疗NSTEMI患者预后的高危因素(P<0.05)。血清sST2联合IL-17检测诊断PCI治疗NSTEMI患者预后的曲线下面积、灵敏度、特异度、约登指数均高于两者单一检测(P<0.05)。结论血清sST2、IL-17联合检测在PCI治疗NSTEMI患者预后中的诊断价值高,对合理防治方案的制定提供参考。

Objective To explore the value of soluble growth stimulation expressed gene 2(sST2)protein and interleukin-17(IL-17)in prognostic evaluation of patients with acute non-ST elevation myocardial infarction(NSTEMI)treated with PCI.Methods Clinical data of 80 patients with NSTEMI who were admitted to our hospital were collected.According to presence or absence of adverse cardiovascular events,they were divided into good prognosis group and poor prognosis group.Univariate and multivariate logistic regression analyses were performed.ROC curve analysis was applied to analyze the prognostic evaluation value of serum sST2 and IL-17 levels.Results There were no significant differences in gender,age,smoking history,underlying disease types and vessel types of infectious lesions between the two groups(P>0.05).The levels of serum TC,LDL-C,sST2 and IL-17 in the good prognosis group were significantly lower than those in the poor prognosis group(P<0.05).The results of logistic regression analysis showed that levels of sST2 and IL-17 were high-risk factors of prognosis in NSTEMI patients undergoing PCI(P<0.05).ROC curve analysis indicated that area under the curve,sensitivity,specificity and Youden index of serum sST2 combined with IL-17 for prognosis were higher than those of single detection.Conclusion The value of serum sST2 combined with IL-17 is high for prognosis of NSTEMI patients undergoing PCI.It provides reference for formulation of reasonable prevention and treatment plans.