摘要
Novel organic compounds(1~8) were designed, synthesized and characterized by IR, ~1H NMR, H RMS, and single-crystal X-ray crystallography. The anticancer activities of these compounds were investigated against four human lung cancer cells(H20, H2227, H69 and H524) by 3-(4,5)-dimethylthiahiazo(-z-y1)-3,5-di-phenytetrazoliumromide(MTT) assay. Furthermore, by taking compounds 1 and 5 as representatives, molecular docking studies supported the biological assay data, suggesting that compared with 1, compound 5 has stronger interaction with protein.
作者
LI Di
李迪(Inner Mongolia University for Nationalities,Tongliao 028000,China)
基金
supported by the Project of Inner Mongolia University for the Nationalities (No. NMDYB15064)
Science Research Project of Inner Mongolia Education Department (No. NJZY20114)。
