环状RNA在女性生殖系统中的研究进展

Research Progress in Circular RNA in Female Reproductive System

环状RNA(circRNA)是经反向剪接而成的一类共价闭合的环状非编码RNA,广泛存在于各种真核生物内,可通过结合RNA结合蛋白或海绵效应吸附微小RNA(miRNA)等机制发挥细胞信号传导、基因调控、蛋白质翻译等生物功能,参与各种生理和病理过程。研究发现,circRNA异常可能与女性生殖道肿瘤和女性内分泌相关疾病的发生、发展相关。其在女性生殖系统疾病中的潜在机制研究也逐渐深入。CircRNA保守、稳定、组织特异的生物学特性,使其有很大潜力作为女性生殖系统疾病诊断的生物标志物及治疗靶点。

Circular RNA(circRNA) is a large class of non-coding RNAs in eukaryotes which is bonded by the reverse splicing. Through binding with corresponding microRNAs or directly contacting with proteins, circRNA exerts the biological functions of cell signal transduction, gene regulation and protein translation, and plays a primarily important role in various physiological and pathological processes. Study found that the abnormality of circRNA could be related to the occurrence and development of female genital tract tumors and female endocrinerelated diseases. The potential mechanism of circRNA in female reproductive system and diseases has also been gradually investigated. Owing to the biological characteristics of conservative, stability and tissue specificity,circRNA may be a class of potential diagnostic biomarkers and therapeutic targets of female reproductive system diseases.