鼠神经生长因子治疗重症脑梗死160例临床效果分析

Clinical effect analysis of mouse nerve growth factor in treatment of 160 cases of severe cerebral infarction

目的评估鼠神经生长因子(mNGF)对重症脑梗死患者神经功能康复的影响。方法选择台州市中心医院2017年1月至2018年12月收治的160例急性重症脑梗死患者为研究对象。将患者按随机数字表法分为观察组与对照组,每组80例。对照组给予西医常规治疗;观察组在西医常规基础上加用mNGF 18μg,每日1次肌肉注射(肌注),连用3周。观察两组患者神经功能和日常生活活动能力(ADL)改善程度;并记录两组并发症发生率。结果两组治疗3周后美国国立卫生研究院卒中评分量表(NIHSS)评分和ADL评分均较治疗前明显降低,观察组治疗后NIHSS评分(分:14.47±4.87比16.71±5.05)和ADL评分(分:26.25±6.63比32.37±7.34)明显低于对照组(均P<0.05)。并发症方面,观察组应激性溃疡出血〔5.0%(4/80)比15.0%(12/80)〕、肺部感染〔18.8%(15/80)比33.8%(27/80)〕、泌尿系感染〔7.5%(6/80)比17.5%(14/80)〕发生率均较对照组明显降低(均P<0.05),褥疮发生率较对照组有所降低〔1.2%(1/80)比5.0%(4/80)〕,但两组比较差异无统计学意义(P>0.05)。结论在脑梗死患者的临床治疗中,采用常规治疗联合mNGF方案,可显著改善患者的神经功能缺损症状,减少并发症的发生,提高临床疗效,加快患者神经功能康复。

Objective To evaluate the effect of mouse nerve growth factor(mNGF)on the neurological rehabilitation of patients with severe cerebral infarction.Methods The 160 patients with acute severe cerebral infarction hospitalized in Taizhou Central Hospital from January 2017 to December 2018 were selected as research objects.The patients were divided into observation group and control group according to the random number table method,80 cases in each group.The control group was treated with routine Western medicine;the observation group was treated with mNGF 18μg on the basis of routine Western medicine,by intramuscular injection,once daily for 3 weeks.The improvement of nerve function and ability of daily life(ADL)were observed and the incidence of complications was recorded.Results The National Institute of Health Stroke Scale(NIHSS)score and ADL score of two groups were significantly lower than those of control group after 3 weeks of treatment,the NIHSS score(points:14.47±4.87 vs.16.71±5.05)and the ADL score(points:26.25±6.63 vs.32.37±7.34)of observation group were significantly lower than those of control group after treatment(both P<0.05).In terms of complications,the patients with stress ulcer bleeding[5.0%(4/80)vs.15.0%(12/80)],pulmonary infection[18.8%(15/80)vs.33.8%(27/80)],and urinary infection[18.8%(15/80)vs.33.8%(27/80)]in observation group were significantly less than those in control group(all P<0.05),while the patients with bedsore were slightly less than that in control group[1.2%(1/80)vs.5.0%(4/80)],without significant difference between the two groups(P>0.05).Conclusion In clinical treatment of patients with cerebral infarction,routine treatment combined with mNGF can significantly improve the neurological deficit symptoms,reduce the occurrence of complications,improve the effectiveness of treatment,and accelerate the recovery of neurological function of patients,which is worth popularizing in clinic.