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比索洛尔联合小剂量胺碘酮对老年冠心病伴心室早搏患者心率及心室重构的影响 被引量:1

Effect of bisoprolol combined with low dose amiodarone on heart rate and ventricular remodeling in elderly patients with coronary heart disease with ventricular premature beats
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摘要 目的探讨比索洛尔联合小剂量胺碘酮对老年冠心病伴心室早搏患者心率及心室重构的影响。方法选取2017年1月至2019年2月本院收治的老年冠心病伴心室早搏患者86例,根据盲抽法分为对照组与观察组,各43例。对照组采用小剂量胺碘酮治疗,观察组在对照组基础上采用比索洛尔治疗。比较两组临床疗效、心率及心室重构、不良反应。结果观察组总有效率为97.67%,高于对照组的81.40%,差异具有统计学意义(P<0.05);治疗后,两组LVEF均高于治疗前,LVESV、LA、心率均低于治疗前,且观察组优于对照组,差异具有统计学意义(P<0.05);两组不良反应发生率比较差异无统计学意义。结论采用比索洛尔联合小剂量胺碘酮治疗老年冠心病伴心室早搏可提高临床疗效,改善患者心率及心室重构,且不增加不良反应,安全性较高。 Objective To investigate the effect of bisoprolol combined with low dose amiodarone on heart rate and ventricular remodeling in elderly patients with coronary heart disease with ventricular premature beats. Methods From January 2017 to February 2019, 86 elderly patients with coronary heart disease(CHD) and ventricular premature beats were selected. They were divided into control group and observation group according to blind drawing method, with 43 cases in each group. The control group was treated with low dose amiodarone, and the observation group was treated with bisoprolol on the basis of the control group. Clinical efficacy, heart rate, ventricular remodeling and adverse reactions were compared between the two groups. Results The total effective rate of observation group was 95.35%, higher than that of control group 81.40%, the difference was statistically significant significance(P<0.05). After treatment, the LVEF of both groups were higher than before treatment, the LVESV, LA, heart rate was lower than before treatment, and the observation group was better than the control group, the difference was statistically significant(P<0.05). The incidence of adverse reactions in the two groups was not statistically significant. Conclusion Bisoprolol combined with low-dose amiodarone can improve the clinical efficacy, heart rate and ventricular remodeling in elderly patients with coronary heart disease.
作者 郭小燕 Guo Xiaoyan(Department of Cardiology,Second People's Hospital of Dongying City,Dongying,Shandong,257335,China)
出处 《当代医学》 2020年第21期76-78,共3页 Contemporary Medicine
关键词 老年冠心病伴心室早搏 比索洛尔 小剂量胺碘酮 心率 心室重构 Senile coronary heart disease with ventricular premature beats Bisoprolol Low dose amiodarone Heart rate Ventricular remodeling
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