超选择性动脉介入化疗治疗局部晚期结直肠癌的临床研究

Clinical study of superselective arterial interventional chemotherapy for local advanced colorectal cancer

目的探讨超选择性动脉介入化疗治疗局部晚期结直肠癌(CRC)的临床疗效。方法选取2017年10月至2019年4月重庆市中医院及重庆急救医疗中心的33例局部晚期CRC患者,并根据治疗方式分为常规化疗组(18例)和动脉介入化疗组(15例)。常规化疗组采用奥沙利铂静脉给药+卡培他滨口服给药方式,动脉介入化疗组采用奥沙利铂肿瘤供血动脉给药+卡培他滨口服给药方式。比较两组肿瘤退缩率、化疗有效率及不良反应发生率。结果两组化疗2、4个疗程后肿瘤退缩率、化疗疗效比较,差异均有统计学意义(P<0.05)。两组化疗不良反应发生率比较,差异均无统计学意义(P>0.05)。结论对于局部晚期CRC,超选择性动脉介入化疗可更快速、更有效地使局部肿瘤降期,且化疗不良反应少,有一定临床推广价值。

Objective To explore the clinical effect of superselective arterial interventional chemotherapy for local advanced colorectal cancer(CRC).Methods From October 2017 to April 2019,33 patients with locally advanced CRC in Chongqing Traditional Medicine Hospital and Chongqing Emergency Medical Care were selected and divided into conventional chemotherapy group(18 cases)and arterial interventional chemotherapy group(15 cases)according to the treatment mode.The conventional chemotherapy group was given oxaliplatin intravenously and capecitabine orally,and the arterial interventional chemotherapy group was given oxaliplatin tumor blood supply artery and capecitabine orally.The tumor regression rate,chemotherapy efficacy rate and adverse reactions rate were compared between the two groups.Results There were significant differences between the two groups in the rate of tumor regression and the effect of chemotherapy after two or four courses of chemotherapy(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion For the local advanced CRC,superselective arterial interventional chemotherapy can make the local tumor fall to the stage more quickly and effectively,and the adverse reactions of chemotherapy are less,so it has a certain clinical value.