山茱萸化学成分、生物活性、复方应用及质量控制研究进展

Research progress on chemical constituents,bioactivities, formula applications and quality control of Cornus officinalis

山茱萸Cornus officinalis是一种重要的中药资源,中药的开发利用在天然产物的研究领域占据了重要的地位。山茱萸主要包括环烯醚萜、鞣质、黄酮、三萜、芳香酚酸、挥发油类等化学成分。现代研究表明,山茱萸具有肝肾保护,抗糖尿病,抗氧化,抗衰老,神经保护,抗肿瘤活性和调节毛发生长等生物活性。此外,含山茱萸的复方临床多用于补虚药和收涩药,且其质量控制分析方法多涉及为高效液相色谱法(HPLC)、液质联用(LC-MS)、气质联用(GC-MS)、电感耦合等离子体质谱(ICP-MS)。经查阅近40年国内外文献,对山茱萸化学成分、生物活性、复方应用及质量控制进行综述,为该药用植物进一步深入开发与应用提供参考依据。

Cornus officinalis is an important resource of Traditional Chinese Medicine(TCM).The development and utilization of TCM has occupied an important position in the research field of natural products.And the chemical constituents from C.officinalis mainly include iridoids,tannins,flavonoids,triterpenes,aromatic,phenolic acids,and essential oils.Meanwhile,C.officinalis had a wide range of wide pharmacological activities,such as hepatic and renal protection,antidiabetes,antioxidation,antitumor activity,and hair growth regulation.In addition,the formulas containing C.officinalis are clinically used for tonic and astringent medicine.The analytical methods of quality control about C.officinalis mainly include high performance liquid chromatography(HPLC),liquid chromatography-mass spectrometry(LC-MS),gas chromatography-mass spectrometry(GC-MS),and inductively coupled plasma mass spectrometry(ICP-MS).This review summarizes the chemical constituents,pharmacology,formula applications and quality control of C.officinalis in the recent 40-year literatures in order to promote the further rational development and utilization of the C.officinalis.