帕金森病抑郁症状发病机制的研究进展

Research progress on the pathogenesis of depressive symptoms in Parkinson′s disease

帕金森病(PD)是一种以黑质多巴胺能神经元变性死亡为主要病理改变的神经系统变性疾病。该病多见于60岁以上人群,男性居多,其主要有两大类症状,即以静止性震颤、肌强直、运动迟缓以及姿势平衡障碍为主要特征的运动症状和以感觉障碍、睡眠障碍、自主神经功能障碍以及精神障碍为主要表现的非运动症状。其中,抑郁是PD最常见的非运动症状,其患病率约50%左右,但其发病机制尚未明确。本文结合近几年国内外发表的经典临床试验,对PD伴发抑郁的发病机制进行综述。

Parkinson′s disease(PD)is a progressive neurodegenerative disease,resulting from the degeneration and loss of dopaminergic neurons in the substantia nigra of midbrain,which is more common in men over the age of 60.PD affects movement,producing motor symptoms such as static tremor,rigidity,slowness of movement and postural instability.Non-motor symptoms of PD include sensory and sleep disorders,autonomic dysfunction,and neuropsychiatric problems.Depression is the most common non-motor symptom of PD,and its prevalence rate is about 50%,but its pathogenesis is not yet clear.This paper reviews the pathogenesis of PD with depression.