同型半胱氨酸与尿微量白蛋白联合检测在糖尿病肾病中的临床诊断价值

The Clinical Value of the Detection of Hcy and U-mALB in Diabetic Nephropathy

目的探讨同型半胱氨酸(homocysteine,Hcy)和尿微量白蛋白(urine microalbumin,U-mALB)联合检测在糖尿病肾病(diabetic nehropathy,DN)中的临床诊断意义。方法选取2016年3月至2019年3月来我院就诊并被确诊为糖尿病肾病的患者120例为研究对象。另选取来我院进行常规体检且身体健康的60例健康志愿者作为健康对照组。分析血液中Hcy和尿液中U-mALB的水平以及其在糖尿病肾病临床诊断中的价值。结果糖尿病肾病患者体内Hcy和U-mALB水平均显著高于对照组,差异具有统计学意义。同时血清中总胆固醇和血清胰岛素的水平与U-mALB水平具有一定相关性。Hcy在糖尿病肾病患者中的检测灵敏度为65.83%(79/120)。而U-mALB在糖尿病肾病患者中的检测灵敏度为43.33%(52/120)。糖尿病肾病患者Hcy和U-mALB全为阴性的概率为23.33%(28/120)。结论Hcy和U-mALB在糖尿病肾病患者临床检测中具有一定灵敏度,可作为早期临床检测的有效指标之一。

Objective To explore the diagnostic value of the combination of Hcy and U-mALB in Diabetic Nephropathy(DN).Methods A total of 120 DN patients who were diagnosed in our hospital from March,2016 to March,2019 were collected for the current study,while 60 healthy person,who received physical examination,were collected as controls.The levels of Hcy and U-mALB were detected for analyzing their diagnostic values.Results The contents of Hcy and U-mALB in DN patients were significantly higher than those in the control patients.The levels of total cholesterol and serum insulin were associated with the level of U-mALB in DN patients.The sensitivity of Hcy in DN diagnosis was 65.83%(79/120),while the sensitivity of U-mALB in DN diagnosis was 43.33%(52/120).The negative rate of both Hcy and U-mALB in DN was 23.33%(28/120).Conclusion The combination detection of Hcy and U-mALB in DN diagnosis has a high sensitivity,and can be considered as the effective diagnosis markers.