摘要
目的探讨不同性别代谢综合征(MS)与颈动脉粥样硬化的关系。方法将3 598例上海市健康体检人群纳入研究,其中男2 847例,女751例。比较不同性别代谢综合征组(MS组)与无代谢综合征组(无MS组)人群颈动脉粥样硬化的患病率;并比较不同性别MS人群伴与不伴颈动脉粥样硬化的年龄、腰围(W)、腰臀围比(WHR)、体质量指数(BMI)、收缩压(SBP)、舒张压(DBP)、三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、空腹血糖(FBG)、血尿酸(SUA)。以有无颈动脉粥样硬化为因变量,年龄、有无MS、WHR、TC、LDL-C、SUA为调整变量,按不同性别分别进行Logistic回归分析,了解不同性别人群中MS对颈动脉粥样硬化患病率的影响。结果不同性别MS组颈动脉粥样硬化的患病率都高于无MS组,差异有统计学意义(P<0.01)。不管是MS伴颈动脉粥样硬化组还是MS伴颈动脉正常组,男性与女性的年龄、W、WHR、SUA差异都有统计学意义(P<0.05),MS伴颈动脉粥样硬化组男性与女性HDL-C差异有统计学意义(P<0.01),MS伴颈动脉正常组男性与女性HDL-C差异无统计学意义。回归分析男性组中对颈动脉粥样硬化患病率影响较大的因素为年龄、MS(P<0.01),女性组中对颈动脉粥样硬化患病率影响较大的因素为年龄(P<0.01)。结论男性代谢综合征与颈动脉粥样硬化患病率相关,女性代谢综合征与颈动脉粥样硬化患病率无关。
Objective To investigate the correlation between metabolic syndrome(MS)and carotid atherosclerosis of people with different gender.Methods 3598 people from Shanghai city who participated in the physical examination were involved in the study,with 2847 male and 751 female.The prevalence of carotid atherosclerosis with different gender in people who were diagnosed with MS and people with non-metabolic syndrome(NMS)were then compared.In addition,age,waistline(W),waist-to-hip ratio(WHR),body mass index(BMI),systolic pressure(SBP),diastolic pressure(DBP),triglyceride(TG),total cholesterol(TC),low density lipoprotein cholesterol(LDL-C),high density lipoprotein cholesterol(HDL-C),fasting blood-glucose(FBG)and serum uric acid(SUA)with different gender in people with both MS and carotid atherosclerosis and people with MS but without carotid atherosclerosis were compared.Carotid atherosclerosis or not was set as the dependent variable,while age,MS or not,WHR,TC,LDL-C and SUA were set as adjusted variables.The data was analyzed by logistic regression method with different gender.The impacts of MS on prevalence of carotid atherosclerosis with different gender were evaluated.Results The prevalence of carotid atherosclerosis was higher in the MS group than in the NMS group,for both male and female(P<0.01).In the MS group,with or without carotid atherosclerosis,age,W,WHR and SUA in male were significantly different from those in female(P<0.05).In the MS with carotid atherosclerosis group,HDL-C in male was significantly different from that in female(P<0.01),while in the MS without carotid atherosclerosis group,HDL-C in male was not different from that in female.Logistic regression analysis showed that age and MS were the uppermost factors influencing prevalence of carotid atherosclerosis in male(P<0.01).Age was the uppermost factors influencing prevalence of carotid atherosclerosis in female(P<0.01).Conclusion In male population,MS is related to the prevalence of carotid atherosclerosis.But in female population,it is not related to the prevalence of carotid atherosclerosis.
作者
李晔
李金鹆
刘梅
LI Ye;LI Jinyu;LIU Mei(Huadong Sanatorium,Wuxi 214065,China)
出处
《标记免疫分析与临床》
CAS
2020年第6期1015-1018,共4页
Labeled Immunoassays and Clinical Medicine
关键词
性别
代谢综合征
颈动脉粥样硬化
Gender
Metabolic syndrome
Carotid atherosclerosis