高血压相关神经内分泌肿瘤:现状与进展

Neuroendocrine Neoplasias Related to Hypertension:Current Status and Progress

神经内分泌肿瘤(neuroendocrine neoplasia,NEN)较罕见,部分NEN可分泌过量激素,引起患者血压升高,是继发性高血压的重要病因。导致高血压的NEN包括嗜铬细胞瘤/副神经节瘤、垂体生长激素瘤、垂体促肾上腺皮质激素瘤、甲状旁腺腺瘤/腺癌以及异位分泌激素的NEN。此类患者除高血压症状外,常伴有其他典型临床特征,但部分患者临床症状并不明显,需在早期加以识别。近年来,随着新的核素显像技术等应用于临床,极大提高了此类疾病的检出率,使更多患者得到及时诊治。

Neuroendocrine neoplasias(NENs) are rare. Some NENs secrete hormone, thus causing hypertension of the patients. NENs are important causes of secondary hypertension, which include pheochromocytoma and paraganglioma, growth hormone-secreting pituitary adenoma, adrenocorticotropic hormone-secreting pituitary adenoma, parathyroid adenoma and carcinoma, and ectopic hormone-secreting NENs. Apart from hypertension, most NEN patients had other typical clinical features that need to be identified at early stage. In recent years, with the application of new technologies of nuclide imaging, the detection rate of these diseases has been greatly improved, and more patients can be diagnosed and treated early.