大落新妇根中三萜类成分的研究

Triterpenes from Astilbe grandis

目的研究大落新妇Astilbe grandis Stapf ex Wils.根中三萜类成分。方法大落新妇根甲醇提取物采用硅胶和Sephadex LH-20进行分离纯化,根据理化性质及波谱数据鉴定所得化合物的结构。结果从中分离得到9个化合物,分别鉴定为3β-hydroxyolean-12-en-27-oic acid(1)、3α-hydroxyolean-12-en-27-oic acid(2)、3α-acetoxyolean-12-en-27-oic acid(3)、3β-acetoxyolean-12-en-27-oic acid(4)、3β,24-dihydroxyolean-12-en-27-oic acid(5)、3α,24-dihydroxyolean-12-en-27-oic acid(6)、methyl 3α-acetoxyolean-12-en-27-oate(7)、3β,6β-dihydroxyolean-12-en-27-oic acid(8)、3β,6β,24-trihydroxyolean-12-en-27-oic acid(9)。结论所有化合物均为首次从该植物中分离得到。

AIM To study the triterpenes from Astilbe grandis Stapf ex Wils.METHODS The methanol extract from the roots of A.grandis was isolated and purified by silica and Sephadex LH⁃20,then the structures of obtained compounds were identified by physicochemical properties and spectral data.RESULTS Nine compounds were isolated and identified as 3β⁃hydroxyolean⁃12⁃en⁃27⁃oic acid(1)、3α⁃hydroxyolean⁃12⁃en⁃27⁃oic acid(2)、3α⁃acetoxyolean⁃12⁃en⁃27⁃oic acid(3)、3β⁃acetoxyolean⁃12⁃en⁃27⁃oic acid(4)、3β,24⁃dihydroxyolean⁃12⁃en⁃27⁃oic acid(5)、3α,24⁃dihydroxyolean⁃12⁃en⁃27⁃oic acid(6)、methyl 3α⁃acetoxyolean⁃12⁃en⁃27⁃oate(7)、3β,6β⁃dihydroxyolean⁃12⁃en⁃27⁃oic acid(8)、3β,6β,24⁃trihydroxyolean⁃12⁃en⁃27⁃oic acid(9).CONCLUSION All compounds are isolated from this plant for the first time.