假蒟化学成分的研究

Chemical constituents from Piper sarmentosum

目的研究假蒟Piper sarmentosum Roxb.的化学成分。方法假蒟80%乙醇提取物乙酸乙酯萃取部位采用硅胶柱、Sephedex LH-20、TLC和重结晶等进行分离纯化,根据理化性质及波谱数据鉴定所得化合物的结构。结果从中分离得到8个化合物,分别鉴定为sesamin(1)、pellitorine(2)、1-nitrosoimino-2,4,5-trimethoxybenzene(3)、N-(3-phenylpropanoyl) pyrrole(4)、3-(4′-methoxyphenyl)propanoyl pyrrole(5)、β-sitosterol(6)、piperumbellactam A(7)、6,7-dimethoxy-4-hydroxy-1-naphthoic acid(8)。结论化合物5、7~8为首次从该植物中分离得到。

AIM To study the chemical constituents from Piper sarmentosum Roxb.METHODS The ethyl acetate fraction of 80%ethanol extract from P.sarmentosum was isolated and purified by silica,Sephedex LH⁃20,TLC and recrystallization,then the structures of obtained compounds were identified by physicochemical properties and spectral data.RESULTS Eight compounds were isolated and identified as sesamin(1),pellitorine(2),1⁃nitrosoimino⁃2,4,5⁃trimethoxybenzene(3),N⁃(3⁃phenylpropanoyl)pyrrole(4),3⁃(4′⁃methoxyphenyl)propanoyl pyrrole(5),β⁃sitosterol(6),piperumbellactam A(7),6,7⁃dimethoxy⁃4⁃hydroxy⁃1⁃naphthoic acid(8).CONCLUSION Compounds 5,7⁃8 are isolated from this plant for the first time.