乳腺癌肝转移的机制及治疗

Mechanism and treatment progress of liver metastasis in breast cancer

乳腺癌是女性最常见的恶性肿瘤,也是女性肿瘤相关性死亡的主要原因。乳腺癌发生远处转移是其死亡的主要原因之一,骨、肺、肝和脑是转移主要的靶器官;肝脏是实体肿瘤常见的转移部位,是乳腺癌第三常见的转移部位。乳腺癌肝转移的过程是多步骤的,是乳腺癌细胞和肝组织微环境中的多种因素共同参与的,进一步了解乳腺癌肝转移的机制对指导临床治疗至关重要。作者论述了乳腺癌肝转移的机制及治疗进展。

Breast cancer is the most common malignancy in women and the leading cause of tumor-related death in women.The main cause of death in patients with breast cancer is metastasis.Bone,lung,liver and brain are the main target organs.Liver is the most common metastatic site of solid tumors and the third most common metastatic site of breast cancer.The process of breast cancer liver metastasis(BCLM)is multi-steps,which is the result of breast cancer cells and microenvironment of liver tissue.Further understanding the mechanisms of BCLM is very important to clinical treatments.This article reviews the mechanisms and clinical treatments of BCLM.