参芪扶正注射液治疗晚期肺癌的疗效及对免疫功能、生活质量的影响

Efficacy of Shenqi Fuzheng Injection in the treatment of advanced lung cancer and its impact on immune function and quality of life

目的探讨参芪扶正注射液治疗晚期非小细胞肺癌(NSCLC)的临床疗效及对免疫功能、生活质量的影响。方法选取收治的80例晚期NSCLC患者,随机分为研究组及对照组,两组各40例。对照组患者单纯采用GP方案(吉西他滨^+顺铂)化疗,研究组在对照组治疗基础上联合参芪扶正注射液治疗。比较两组患者的临床疗效,并发症发生情况,免疫功能(CD3^+、CD4^+、CD4^+/CD8^+),生活质量评分情况。结果两组患者治疗后总有效率比较差异无统计学意义(P>0.05)。研究组患者治疗后化疗不良反应改善情况、免疫功能及生活质量改善情况均显著优于对照组,差异有统计学意义(P<0.05)。结论参芪扶正注射液不仅可减轻晚期NSCLC患者化疗的不良反应,同时还可提高其免疫功能及预后,值得临床推广。

Objective To investigate the clinical efficacy of Shenqi Fuzheng injection in the treatment of advanced non-small cell lung cancer(NSCLC)and its impact on its immune function and quality of life.Methods Eighty patients with advanced NSCLC were selected and randomly divided into a study group and a control group,40 cases each.The patients in the control group were treated with GP regimen(gemcitabine+cisplatin),and the study group was treated with Shenqi Fuzheng injection on the basis of the control group.The clinical efficacy,occurrence of complications,immune function(CD3^+,CD4^+,CD4^+/CD8^+)and quality of life scores were compared between the two groups.Results There was no statistically significant difference in the total effective rate between the two groups after treatment(P>0.05).The improvement of chemotherapy adverse reaction,immune function and quality of life in the study group were significantly better than those in the control group,the difference was statistically significant(P<0.05).Conclusion Shenqi Fuzheng injection can not only reduce the adverse reactions of chemotherapy in patients with advanced NSCLC,but also improve its immune function and prognosis.It is worthy of clinical promotion.