上皮样血管瘤16例临床与病理分析

Clinical and pathological analyses of epithelioid hemangioma in sixteen cases

目的:探讨上皮样血管瘤(EH)的临床及组织病理学特征。方法:回顾性分析16例已确诊患者的临床及病理资料,并对相关文献进行综述。结果:16例患者中女8例,男8例;平均年龄(45.44±12.52)岁;病程3个月~20年;皮损主要表现为红色至暗红色丘疹、结节,可伴瘙痒和糜烂,好发于头皮、耳部,其中发生在头部10例、耳部5例、外阴1例;皮损单发者5例,多发者11例。皮损组织病理学检查均具有典型的血管增生,管壁增厚,内皮细胞呈上皮样突向管腔,管周大量淋巴细胞及嗜酸性粒细胞浸润。结论:上皮样血管瘤少见,诊断需要临床与病理密切结合。加强对该病的认识,可避免误诊误治。

Objective:To investigate the clinical and pathological features of epithelioid hemangioma(EH). Methods:Retrospective analyses were performed on the clinical and pathological data of sixteen patients with EH, and related literatures were reviewed.Results:Sixteen patients, including 8 females and 8 males, were aged 45.44±12.52 years, with 3-month to 12-year history of EH. All subjects showed typical clinical and histopathological features.The main manifestations of the skin were red to dark red papules and nodules, some of which were accompanied with pruritus and erosion. Involvements of the head, ears, and vulva were 10, 5 and 1 cases, respectively. Five cases showed single skin lesion, and 11 cases with multiple skin lesions. Histopathological features included typical vascular proliferation, thickened vessel walls, epithelioid-like endothelial cells protruding into the lumen, and perivascular infiltration of large amounts of lymphocytes and eosinophils. Conclusions:Epithelioid hemangioma is rare. The diagnosis should be based on both clinical and pathological features. Enhancing awareness of this disease would be helpful to avoid misdiagnosis and improper treatment.