正常人群骶髂关节脂肪含量的初步定量分析

Preliminary quantitative analysis of fat fraction of sacroiliac joint in normal population

目的:探讨基于磁共振定量非对称回波的最小二乘估算法迭代水脂分离序列(IDEAL-IQ)的正常人群骶髂关节脂肪含量的初步定量评价。方法:前瞻性分析2017年4月-2017年11月中国中医科学院西苑医院接诊的60例正常骶髂关节的影像和临床资料。按照年龄(15~30岁、31~50岁、≥51岁)、性别、BMI(<18.5,18.5~23.9,>24.0)进行分组,测量每例受检者骶髂关节脂肪分量图像上髂侧(Fi)和骶侧(Fs)的脂肪分数值(FF)。分别采用三因素、两因素以及多元方差分析方法对性别、年龄分组、BMI分组对Fi、Fs的影响进行分析。结果:31~50岁组、≥51岁组组内Fi和Fs差异有统计学意义(P=0.006,P=0.028);≥51岁组男性与女性Fi和Fs差异有统计学意义(P值分别为0.009、0.004);三组间BMI平均值差异无统计学意义(F=0.717,P=0.493)。对于Fi和Fs,不存在性别、年龄分组、BMI分组三因素交互作用[F(2,45)=1.538,P=0.226;F(2,45)=0.371,P=0.692]、不存在两因素交互作用(性别和年龄分组,性别和BMI分组,年龄分组和BMI分组,P均>0.05);多元方差分析显示年龄对于Fi和Fs的影响差异具有统计学意义(F=4.252,P=0.019,partialη2=0.136;F=12.694,P<0.001,partialη2=0.320);性别对于Fs的影响差异具有统计学意义(F=9.007,P=0.004,partialη2=0.143)。结论:基于IDEAL-IQ脂肪定量技术可定量分析正常人群骶髂关节脂肪含量。

Objective:To evaluate the feasibility of fat quantitation in the sacroiliac joint of healthy volunteers by iterative decomposition of water and fat with echo asymmetry and least square estimation-iron quantification(IDEAL-IQ).Methods:Between April 2017 and November 2017,sixty healthy volunteers at the Xiyuan Hospital of the China Academy of Chinese Medical Sciences were retrospectively enrolled.They were divided by age(15~30 years group,31~50 years group,≥51 years group),gender(male,female)and body mass index(BMI)(<18.5,18.5~23.9,>24.0.Fat fraction of iliac-side(Fi)and sacral-side(Fs)were obtained for all groups.Three factors,two-factors and multivariate analysis of variance was used to analyze the effects of gender,age and BMI groups on Fi and Fs.Results:Fi and Fs were statistically significant in both 31~50 years group and≥51 years group(P=0.006,P=0.028)and between males and females in over 51 years old group(P=0.009,0.004).There was no significant difference in BMI mean value among the three groups(F=0.717,P=0.493).Variance analysis of three factors and double factors analysis showed that the interaction between gender,age groups and BMI grade had no statistical significance on both Fi and Fs(three factors:F(2,45)=1.538,P=0.226),double factor:gender and age group,gender and BMI group,age group and BMI group),all P value>0.05).Both Fi and Fs have all been influenced by age(F=4.252,P=0.019,partialη2=0.136;F=12.694,P<0.001,partialη2=0.320),srespectively.Fs has been influenced by gender(F=9.007,P=0.004,partialη2=0.143).Conclusion:IDEAL-IQ sequence can be used to quantitatively assess sacroiliac joint fat content in healthy volunteers.