ANCA相关性血管炎检测标志物研究新进展

New research progress on detection markers of ANCA-associated vasculitis

抗中性粒细胞胞浆抗体相关性血管炎(AAV)是一类由抗中性粒细胞胞浆抗体(ANCA)介导的以寡免疫复合物沉积为特点的自身免疫性疾病。AAV的发病率较低,容易漏诊,而且病情复杂、进展迅速、预后较差,这些疾病特征均要求需对其进行准确诊断。本文综述了AAV的发病机制和实验诊断标志物的临床应用,以期为AAV的准确诊断提供理论支持,为临床治疗提供帮助。

Antineutrophilic cytoplasmic antibody-associated vasculitis(AAV)is an autoimmune disease characterized by deposition of oligoimmune complexes mediated by Antineutrophilic cytoplasmic antibody(ANCA).The incidence of AAV is low,which is easy to be missed.Moreover,the condition of AAV is complex,the progress is rapid,and the prognosis is poor.Therefore,these characteristics of disease all require accurate diagnosis.In this paper,the pathogenesis of AAV and the clinical application of experimental diagnostic markers are summarized,so as to provide theoretical support for the accurate diagnosis and assistance for clinical treatment of AAV.