bFGF在帕金森病治疗中的作用机制研究进展

Research progress on the mechanism of bFGF in the treatment of Parkinson's disease

帕金森病(Parkinson's disease,PD)是一种由黑质纹状体多巴胺能神经元变性丢失引起的神经退行性疾病,主要表现为静止性震颤、肌强直、运动迟缓。目前临床治疗PD的常用药物主要有复方左旋多巴制剂、多巴胺受体激动剂等,但是长期用药不良反应及并发症明显。近年有研究证实碱性成纤维细胞生长因子(Basic fibroblast growth factor,bFGF)具有神经保护作用,有望成为PD治疗的新方向。本文就bFGF在PD治疗中的作用机制研究进展进行综述。

Parkinson's disease(PD)is a common neurodegenerative disease in the central nervous system,which is mainly caused by the degeneration,and loss of the dopaminergic neurons in the substantia nigra,resulting in resting tremor,myotonic movement and bradykinesia.At present,levodopa and dopamine receptor agonist drugs are the most commonly used for the treatment of PD.However,the long-term use of these drugs could cause obvious side effects and complications.In recent years,basic fibroblast growth factor(bFGF)has been confirmed to have neuroprotective effects,and expected to become a new direction for the treatment of PD.Herein,this article focuses on the mechanism of bFGF in the treatment of this disease.