摘要
目的评价窄谱中波紫外线(NB-UVB)联合卡泊三醇搽剂外用治疗斑块型银屑病的疗效和安全性。方法78例斑块型银屑病患者分为观察组、对照1组和对照2组,每组26例患者。观察组患者给予NB-UVB光疗,每周2次,外用卡泊三醇搽剂,每天2次,疗程6周;对照1组患者外用卡泊三醇搽剂外用,每天2次,疗程6周;对照2组患者给予NB-UVB光疗,每周2次,疗程6周。结果观察组的总有效率84.61%,对照1组总有效率为53.85%,对照2组总有效率为50.00%;观察组总有效率高于对照1组、对照2组,差异均有统计学意义(Z=﹣2.101,P=0.036;Z=﹣2.534,P=0.011);对照1组与对照2组疗效比较差异无统计学意义(Z=﹣0.567,P=0.570)。3组患者均无明显不良反应。结论NB-UVB联合外用卡泊三醇搽剂外用治疗斑块型银屑病是安全的、有效的。
Objective To observe the clinical effect and safety of NB-UVB combined with topical Calcipotriol liniment in the treatment of plaque-type psoriasis vulgaris.Methods Seventy-eight cases of plaquetype psoriasis vulgaris were randomly divided into observation group,control group 1,and control group 2.Twenty-six patients in the observation group were treated with NB-UVB 2 times weekly and topical Calcipotriol liniment twice every day for 6 weeks.Twenty-six patients in the control group 1 were treated with topical Calcipotriol liniment twice every day for 6 weeks.Twenty-six patients in the control group 2 were treated with NB-UVB 2 times weekly for 6 weeks.Results The total effective rates in the observation group,the control group 1,and the control group 2 were 84.61%,53.85%,and 50.00%,respectively.The total effective rate of the observation group was significantly higher than those of the control group 1 and the control group 2(Z=-2.101,P=0.036;Z=-2.534,P=0.011);the total effective rate of the control group 1 was similar to that of the control group 2(Z=-0.567,P=0.570).No marked side effects were observed in the 3 groups.Conclusion NB-UVB combined with topical Calcipotriol liniment is effective and safe in the treatment of plaque-type psoriasis vulgaris.
作者
王笑宇
刘成
Wang Xiaoyu;Liu Cheng(Department of Dermatology,Guangdong Armed Police Corps General Hospital of Guangzhou Medical University,Guangzhou 510517,China)
出处
《国际医药卫生导报》
2020年第13期1949-1950,1985,共3页
International Medicine and Health Guidance News