奥沙利铂结合表柔比星介入治疗原发肝癌效果及对血清甲胎蛋白水平的影响

Effect of oxaliplatin combined with epirubicin in interventional treatment of primary liver cancer and its effect on serum alpha-fetoprotein level

目的:探讨奥沙利铂联合表柔比星介入治疗原发肝癌的疗效及对血清甲胎蛋白(Alpha-Fetoprotein,AFP)水平的影响。方法:选取鹤山市人民医院2015年6月-2017年6月收治的原发肝癌患者80例,随机数字表法分为对照组(碘油肝动脉介入栓塞治疗,40例)与观察组(奥沙利铂联合表柔比星肝动脉介入栓塞治疗,40例),随访2年,比较两组治疗效果、AFP、癌胚抗原199(Carcinoembryonic Antigen 199,CA199)、谷氨酸转移酶(Glutamate Transferase,GGT)水平、2年生存率及不良反应发生率。结果:观察组治疗总有效率高于对照组(P <0.05);观察组AFP、CA199、GGT水平低于对照组(P <0.05);观察组2年生存率高于对照组(P <0.05);两组不良反应发生率比较差异无统计学意义(P> 0.05)。结论:针对原发肝癌患者,奥沙利铂联合表柔比星肝动脉介入栓塞治疗可提高临床疗效,降低肿瘤标记物水平,提高2年生存率,且较为安全。

Objective: To explore the effect of oxaliplatin combined with epirubicin in interventional treatment of primary liver cancer and its effect on serum alpha-fetoprotein level. Methods: 80 cases of primary liver cancer patients admitted to Heshan People’s Hospital from June 2015 to June 2017 were selected and randomly divided into the control group(iodox hepatic artery interventional embolization treatment, 40 cases) and the observation group(oxaliplatin combined with epirubinin hepatic artery interventional embolization treatment, 40 cases) by number table method, and were followed up for 2 years. The therapeutic effects of AFP, oncoembryonic antigen 199(CA199), glutamic transferase(GGT), 2-year survival rate and incidence of adverse reactions were compared between the two groups. Results: The total effective rate in the observation group was higher than that in the control group(P<0.05). The levels of AFP, CA199 and GGT in the observation group were lower than those in the control group(P<0.05). The 2-year survival rate in the observation group was higher than that in the control group(P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05). Conclusion: For primary liver cancer patients, oxaliplatin combined with epirubicin can improve the clinical efficacy, reduce the level of tumor markers, improve the 2-year survival rate, and is relatively safe.