FeNO、IgE、FEV1%在支气管哮喘患者中的表达水平及意义

Expression and Significance of FENO、IgE and FEV1% in Patients with bronchial Asthma

目的探讨呼出一氧化氮(FeNO)、总免疫球蛋白E(IgE)、第一秒用力呼气容积占预计值百分比(FEV1%)在支气管哮喘患者中的表达水平及意义。方法采用回顾性方法分析,选取石河子大学医学院第一附属医院自2016年8月-2019年8月收治的70例支气管哮喘患者的临床资料,根据病情分为急性发作组(36例)与缓解组(34例),选取同期来院体检的35例健康者为对照组,比较三组的FeNO、IgE、FEV1%表达水平。结果急性发作组、缓解组的FeNO、IgE水平明显高于对照组(P<0.05),且急性发作组FEV1%水平低于缓解组、对照组(P<0.05)。但缓解组、对照组的FEV1%水平比较无显著差异(P>0.05)。FeNO水平与IgE水平呈正相关(P<0.05),与FEV1%呈负相关(P<0.05)。结论动态检测支气管哮喘患者的FeNO、IgE水平,可了解患者病情严重程度。但FEV1%在支气管哮喘急性发作期有着明显改变,在其他时期及健康人群中无明显变化。

Objective To investigate the expression and significance of FENO,total immunoglobulin E(IgE)and first second exertional volume as a percentage of predicted value(FEV1%)in patients with asthma.Methods The clinical data of 70 patients with asthma admitted to the first affiliated hospital of Shihezi university from August 2016 to August 2019 were analyzed retrospectively,the patients were divided into acute attack group(36 cases)and remission group(34 cases)according to their condition.thirty-five healthy people who came to the hospital for physical examination at the same time were selected as the control group.The expressions of FENO,IgE and FEV1%in the three groups were compared.Results The levels of FENO and IgE in acute attack group and remission group were significantly higher than those in control group(P<0.05),and the FEV1%in acute attack group was lower than those in remission group and control group(P<0.05).However,there was no significant difference in FEV1%between remission group and control group(P>0.05).FENO was positively correlated with IgE(P<0.05)and negatively correlated with FEV1%(P<0.05).Conclusion Dynamic detection of FENO and IgE levels in patients with asthma can reveal the severity of the disease.But the FEV1%had a significant change in asthma,and there was no significant change in other periods and in healthy people.