酒精性肝硬化患者检测同型半胱氨酸的临床意义

Clinical significance of homocysteine detection in patients with alcoholic cirrhosis

目的:探讨同型半胱氨酸(Hcy)水平对酒精性肝硬化患者的临床意义。方法:选取2016年5月-2019年5月酒精性肝硬化患者129例作为试验组;另选取功能性胃肠疾病患者50例作为对照组。比较两组血清Hcy、丙氨酸转氨酶(ALT)及谷氨酰转肽酶(GGT)水平。结果:试验组血Hcy与GGT、ALT水平均明显高于对照组,差异有统计学意义(P<0.05)。酒精性肝硬化Child-Pugh分级结果比较,C级患者Hcy、GGT、ALT生化指标水平均高于A、B级;随着病程进展逐渐升高,Hcy、GGT、ALT之间具有相关性;通过ROC曲线分析可见,酒精性肝硬化诊断效率GGT>Hcy>ALT;通过阳性率比较,酒精性肝硬化C级患者Hcy灵敏度最高,差异有统计学意义(P<0.05)。结论:血清Hcy水平对酒精性肝硬化辅助诊断、病情监测有一定的临床意义。

Objective:To explore the clinical significance of homocysteine(Hcy)level in patients with alcoholic cirrhosis.Methods:From May 2016 to May 2019,129 patients with alcoholic cirrhosis were selected as the experimental group.Another 50 patients with functional gastrointestinal diseases were selected as the control group.We compared the serum homocysteine(Hcy),alanine aminotransferase(ALT)and glutamyltranspeptidase(GGT)levels between the two groups.Results:In the experimental group,the levels of Hcy,GGT and ALT were significantly higher than those in the control group,the difference was statistically significant(P<0.05).Compared with the Child-Pugh classification of alcoholic cirrhosis,the biochemical indexes of Hcy,GGT and ALT in patients with grade C were higher than those in patients with grade A and B.With the progress of the disease,Hcy,GGT and ALT were correlated.ROC curve analysis showed that the diagnostic efficiency of alcoholic cirrhosis was GGT>Hcy>ALT.Compared with the positive rate,the sensitivity of Hcy in patients with alcoholic cirrhosis of grade C was the highest,the difference was statistically significant(P<0.05).Conclusion:The level of Hcy in serum has certain clinical significance in the auxiliary diagnosis and condition monitoring of alcoholic cirrhosis.