恩他卡朋双多巴联合B族维生素治疗中晚期帕金森病临床分析

Analysis of clinical efficacy of stalevo combined with B vitamins in the intermediate and advanced Parkinson’s disease

目的探讨恩他卡朋双多巴联合B族维生素对中晚期帕金森患者的临床疗效。方法收集中晚期帕金森病(PD)患者80例,将其随机分为美多芭组、美多芭+B族维生素组、达灵复组、达灵复+B族维生素组,治疗6个月后评估LD血药浓度、UPDRSⅢ评分、H-Y分级、PSQI、PDQ-39等指标。结果与治疗前相比,达灵复+B族维生素组能显著降低血浆Hcy水平以及PSQI、PDQ-39、UPDRSⅢ评分(P<0.05),提高LD血药浓度(P<0.05);与美多芭+B族维生素组相比,达灵复+B族维生素组可提高LD血药浓度(P<0.05),降低血浆Hcy水平(P<0.05)。结论达灵复联合B族维生素可提高中晚期PD患者LD血药浓度,降低血浆Hcy水平,改善临床症状和生活质量。

Objective To investigate the clinical efficacy of stalevo combined with B vitamins in patients with intermediate and advanced Parkinson’s disease(PD).Methods Eighty patients with intermediate and advanced PD were collected and rando mLy divided into Madopar group,Madopar + B vitamins group,stalevo group and stalevo + B vitamins group.LD blood concentration,UPDRS Ⅲ score,H-Y staging,PSQI,PDQ-39 and other indicators were evaluated after 6 months treatment.Results Compared with before treatment,the stalevo + B vitamins group can significantly decrease plasma Hcy levels and PSQI,PDQ-39,UPDRS Ⅲ scores(P<0.05),increase LD blood concentration(P<0.05).Compared with the Madopar + B vitamins group,the stalevo + B vitamins group can increase LD blood concentration(P<0.05) and reduce the plasma Hcy level(P<0.05).Conclusion Stalevo combined with B vitamins can increase the LD blood concentration,decrease plasma Hcy levels,and improve clinical symptoms and quality of life in patients with intermediate and advanced PD.